Reactome: A Curated Pathway Database

Glycoprotein hormones

Stable Identifier
R-HSA-209822
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

More complex protein hormones have carbohydrate side chains and are called glycoprotein hormones. Hormones in this class are Follicle-stimulating hormone (FSH; follitropin), Luteinizing hormone (LH), Thyroid-stimulating hormone (TSH; thyrotropin) and human chorionic gonadotropin (hCG). The alpha subunit of glycoprotein hormones is a 92 aa peptide and serves as the alpha subunit for FSH, LH, hCG and TSH (Fiddes JC and Goodman HM, 1981). The beta subunits for these hormones are unique and confer biological specificity to them. These two subunits combine via disulphide bonding to produce the mature glycoprotein hormone dimer.

Literature References
PubMed ID Title Journal Year
6267989 Glycoprotein hormones: structure and function Annu Rev Biochem 1981
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Orthologous Events