Tryptophan is hydroxylated

Stable Identifier
R-HSA-209828
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first and rate limiting step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase. The enzyme requires iron(II), tetrahydrobiopterin, and dioxygen cofactors for the hydroxylation of L-tryptophan to 5-hydroxytryptophan. Tryptophan hydroxylase belongs to a small family of monooxygenases that utilize tetrahydrobiopterins. Other members are phenylalanine hydroxylase and tyrosine hydroxylase (Fitzpatrick, PF, 1999; Walther et al, 2003).

Literature References
PubMed ID Title Journal Year
12511643 Synthesis of serotonin by a second tryptophan hydroxylase isoform

Walther, DJ, Peter, JU, Bashammakh, S, Hörtnagl, H, Voits, M, Fink, H, Bader, M

Science 2003
12379098 Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin

Wang, L, Erlandsen, H, Haavik, J, Knappskog, PM, Stevens, RC

Biochemistry 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
tryptophan 5-monooxygenase activity of TPH:Fe++ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created