Reactome | SLC5A5 [plasma membrane]

SLC5A5 [plasma membrane]

Stable Identifier

R-HSA-209833

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NIS, Sodium/iodide cotransporter, SL55_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92911 SLC5A5

Gene Names

SLC5A5, NIS

Chain

chain:1-643

Reference Genes

BioGPS Gene:6528 SLC5A5

COSMIC (genes):SLC5A5 SLC5A5

CTD Gene:6528 SLC5A5

dbSNP Gene:6528 SLC5A5

ENSEMBL:ENSG00000105641 SLC5A5

HGNC:11040 SLC5A5

KEGG:hsa:6528 SLC5A5

Monarch:6528 SLC5A5

NCBI Gene:6528 SLC5A5

OMIM:601843 SLC5A5

UCSC:Q92911 SLC5A5

Reference Transcript

RefSeq:NM_000453.2 SLC5A5

Other Identifiers

11737452_a_at

11755588_a_at

16859657

211123_PM_at

211123_at

32459_at

3824624

3824625

3824626

3824627

3824629

3824630

3824631

3824632

3824633

3824634

3824635

3824636

3824637

3824638

3824639

3824640

3824641

3824642

3824643

6528

8026877

A_23_P101774

GE59330

GO:0003013

GO:0005215

GO:0005515

GO:0005634

GO:0005737

GO:0005886

GO:0006575

GO:0006590

GO:0006811

GO:0006814

GO:0008507

GO:0015111

GO:0015293

GO:0015373

GO:0015705

GO:0016020

GO:0022857

GO:0035725

GO:0042803

GO:0043226

GO:0055085

GO:0070062

GO:0071320

GO:0071371

GO:0150104

GO:1903561

GO:1904200

GO:1904322

GO:1904401

HMNXSV003004377

ILMN_1711275

PH_hs_0005770

TC19000346.hg

U66088_at

g2887404_3p_at

Other forms of this molecule

SLC5A5 T354P [plasma membrane]

SLC5A5 V59E [plasma membrane]

SLC5A5 G93R [plasma membrane]

SLC5A5 R124H [plasma membrane]

SLC5A5 C272* [plasma membrane]

SLC5A5 G395R [plasma membrane]

Inferred To

CG33124-PB [plasma membrane] (Drosophila melanogaster)

Smvt [plasma membrane] (Drosophila melanogaster)

CG31668-PB [plasma membrane] (Drosophila melanogaster)

Dmel\CG2187 [plasma membrane] (Drosophila melanogaster)

Dmel\CG31262 [plasma membrane] (Drosophila melanogaster)

kumpel [plasma membrane] (Drosophila melanogaster)

salt [plasma membrane] (Drosophila melanogaster)

bumpel [plasma membrane] (Drosophila melanogaster)

slc5a5 [plasma membrane] (Danio rerio)

slc5a5 [plasma membrane] (Xenopus tropicalis)

slc-5a12 [plasma membrane] (Caenorhabditis elegans)

Slc5a5 [plasma membrane] (Mus musculus)

Slc5a5 [plasma membrane] (Rattus norvegicus)

dSLC5A3 [plasma membrane] (Drosophila melanogaster)

SLC5A5 [plasma membrane] (Bos taurus)

SLC5A5 [plasma membrane] (Caenorhabditis elegans)

SLC5A5 [plasma membrane] (Canis familiaris)

SLC5A5 [plasma membrane] (Drosophila melanogaster)

SLC5A5 [plasma membrane] (Gallus gallus)

SLC5A5 [plasma membrane] (Sus scrofa)

Homologues of SLC5A5 [plasma membrane] (Caenorhabditis elegans)

Homologues of SLC5A5 [plasma membrane] (Drosophila melanogaster)

dSLC5A2 [plasma membrane] (Drosophila melanogaster)

rumpel [plasma membrane] (Drosophila melanogaster)

SLC5A11 [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

920

ENSEMBL

ENST00000222248, ENSP00000222248

OpenTargets

ENSG00000105641

HPA

ENSG00000105641-SLC5A5

PRO

Q92911

Pharos - Targets

Q92911

GlyGen

Q92911

Orphanet

SLC5A5

HMDB Protein

HMDBP02860

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q6DD88 ATLA3			0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:Q53FV1 ORMDL2	1	ORMDL2 [endoplasmic reticulum membrane] (R-HSA-8865591)	0.527	2
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:P0DPA2 VSIG8			0.527	2

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