Decarboxylation of 5-hydroxytryptophan forms serotonin

Stable Identifier
R-HSA-209859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both dopa and 5-hydroxytryptophan to dopamine and serotonin, respectively. AADC functions as a homodimer, utilizing pyridoxal phosphate as a cofactor.

Literature References
PubMed ID Title Journal Year
2590185 Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase

Ichinose, H, Kurosawa, Y, Titani, K, Fujita, K, Nagatsu, T

Biochem Biophys Res Commun 1989
1540578 Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis

Sumi-Ichinose, C, Ichinose, H, Takahashi, E, Hori, T, Nagatsu, T

Biochemistry 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aromatic-L-amino-acid decarboxylase activity of DDC dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Reviewed
Created