Reactome | Serotonin and melatonin biosynthesis

Serotonin and melatonin biosynthesis

Stable Identifier

R-HSA-209931

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Serotonin (5-HT) is a hormone and neurotransmitter used for regulatory purposes in animal CNS. In the human brain, serotonin is involved in many physiological functions such as sleep, pain, mood and is the precursor to melatonin, a hormone produced in the pineal gland.

Literature References

PubMed ID	Title	Journal	Year
18155917	Melatonin in the skin: synthesis, metabolism and functions Wortsman, J, Slominski, A, Zmijewski, MA, Paus, R, Tobin, DJ	Trends Endocrinol Metab	2008
16942634	Tryptophan metabolism in the central nervous system: medical implications Rook, GA, Lowry, CA, Lightman, SL, Evans, AK, Nutt, DJ, Ruddick, JP	Expert Rev Mol Med	2006