Thyroxine biosynthesis

Stable Identifier
R-HSA-209968
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Thyroxine biosynthesis
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Thyroxine (3,5,3',5'-tetraiodothyronine, T4) promotes normal growth and development. It also regulates heat and energy production. T4 is released from the thyroid gland, the largest endocrine organ in the human body. The primary hormone released is T4 although T3 (3,5,3'-triiodothyronine) is also released in small quantities. Tyrosine residues in thyroglobulin (a glycoprotein scaffold containing many tyrosine residues) are iodinated to form mono- or diiodo-tyrosine which can then couple to form either T3 or T4.
Literature References
PubMed ID Title Journal Year
3297964 Metabolism of the thyroid hormones

Hesch, RD, Köhrle, J, Brabant, G

Horm Res 1987
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
thyroid hormone generation (0006590)
Orthologous Events
Thyroxine biosynthesis (Bos taurus)
Thyroxine biosynthesis (Caenorhabditis elegans)
Thyroxine biosynthesis (Canis familiaris)
Thyroxine biosynthesis (Danio rerio)
Thyroxine biosynthesis (Dictyostelium discoideum)
Thyroxine biosynthesis (Drosophila melanogaster)
Thyroxine biosynthesis (Gallus gallus)
Thyroxine biosynthesis (Mus musculus)
Thyroxine biosynthesis (Rattus norvegicus)
Thyroxine biosynthesis (Saccharomyces cerevisiae)
Thyroxine biosynthesis (Sus scrofa)
Thyroxine biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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