Reactome | FLNA [cytosol]

FLNA [cytosol]

Stable Identifier

R-HSA-210019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Filamin-A

Locations in the PathwayBrowser for interactor UniProt:Q12948 FOXC1

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External Reference Information

External Reference

UniProt:P21333 FLNA

Gene Names

FLNA, FLN, FLN1

Chain

initiator methionine:, chain:2-2647

Reference Genes

BioGPS Gene:2316 FLNA

COSMIC (genes):FLNA FLNA

CTD Gene:2316 FLNA

dbSNP Gene:2316 FLNA

ENSEMBL:ENSG00000196924 FLNA

HGNC:3754 FLNA

KEGG:hsa:2316 FLNA

Monarch:2316 FLNA

NCBI Gene:2316 FLNA

OMIM:300017 FLNA

UCSC:P21333 FLNA

Reference Transcript

Participates

as a member of

as a component of

as an input of

GP1b-IX-V binds filamin (Homo sapiens)

as an output of

RNASEL binds 2'-5' oligoadenylate (Homo sapiens)

Other forms of this molecule

p-S2152-FLNA [cytosol]

FLNA [extracellular region]

Inferred To

cher [cytosol] (Drosophila melanogaster)

fln-1 [cytosol] (Caenorhabditis elegans)

Flna [cytosol] (Mus musculus)

Flna [cytosol] (Rattus norvegicus)

FLNA [cytosol] (Bos taurus)

FLNA [cytosol] (Canis familiaris)

FLNA [cytosol] (Sus scrofa)

abpC [cytosol] (Dictyostelium discoideum)

flna [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000196924

ENSEMBL

ENSP00000358866, ENST00000369850, ENST00000360319, ENSP00000353467, ENSG00000196924

HPA

ENSG00000196924-FLNA

GeneCards

FLNA

PRO

P21333

Pharos - Targets

P21333

GlyGen

P21333

Orphanet

FLNA

PDB

7SC4, 2MTP, 3ISW, 2BRQ, 3RGH, 2JF1, 2AAV, 2W0P, 2WFN, 3CNK, 3HOP, 2BP3, 4P3W, 2J3S, 2K3T, 7SFT, 5XR1, 6EW1, 3HOC, 4M9P, 2K7P, 2K7Q, 3HOR, 6D8C

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.819	6
UniProt:P26010 ITGB7	1	ITGB7 [plasma membrane] (R-HSA-3006427)	0.737	7
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.679	8
UniProt:Q8N264 ARHGAP24	1	ARHGAP24 [cytosol] (R-HSA-2976578)	0.639	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.615	3
UniProt:P08514-1 ITGA2B			0.611	3
UniProt:P05106 ITGB3	3	ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107)	0.611	3
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.61	8
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.602	5
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:Q86SQ0 PHLB2			0.564	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.558	2
UniProt:P26010-1 ITGB7			0.558	2
UniProt:P49286 MTNR1B	1	MTNR1B [plasma membrane] (R-HSA-419349)	0.547	2
UniProt:P26583 HMGB2	1	HMGB2 [nucleoplasm] (R-HSA-266211)	0.547	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.543	5
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.536	3
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.536	2
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.527	2
UniProt:P07228 ITGB1	1	Integrin beta-1 [plasma membrane] (R-GGA-2467444)	0.527	2
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.508	2
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.508	2
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606)	0.508	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	14
UniProt:Q9WMX2-PRO_0000037551			0.463	6
UniProt:Q9WMX2-PRO_0000037548			0.463	6
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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