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Integrin alphaVbeta3 [plasma membrane]
Stable Identifier
R-HSA-210216
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
L1 interaction with Integrins (Homo sapiens)
Integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
L1:Integrin complex [plasma membrane] (Homo sapiens)
Integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)
DMP1:Integrin alphVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)
Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VTN:Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Fibrillin-1 binds integrins (Homo sapiens)
Fibrilin-1:Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Latent TGF-beta-3 binds integrins (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)
COMP pentamer:Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)
Canstatin:Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)
Endostatin:Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:Fibrillin-1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:IBSP [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:PECAM1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:Tenascin [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:VWF multimer [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)
Integrin alphaVBeta1,3,5 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
SPP1:Integrin alphaVBeta1,3,5 [plasma membrane] (Homo sapiens)
Integrin alphaVBeta1,3,5 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Tetrastatin:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)
Integrins alphaVbeta3, alpha3beta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Tumstatin:Integrins alphaVbeta3, alpha3beta1 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alpha3beta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)
Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VTN:Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:PECAM1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
PTK2beta binds alphaVbeta3 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
SRC-1 phosphorylates PTK2-beta (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Latent TGF-beta-3 binds integrins (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
TGF-beta-3:LAP3:LAP3-binding integrins [plasma membrane] (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Participants
components
ITGAV(31-1048) [plasma membrane]
(Homo sapiens)
ITGB3 [plasma membrane]
(Homo sapiens)
Participates
as a component of
DMP1:Integrin alphVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:PECAM1 [plasma membrane] (Homo sapiens)
Tetrastatin:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:Fibrillin-1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:VWF multimer [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:Tenascin [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:IBSP [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alphaVbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alphaVBeta3 [plasma membrane] (Homo sapiens)
as an input of
Interaction of integrin alphaVbeta3 with PECAM1 (Homo sapiens)
Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)
Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)
Interaction of integrin alphaVbeta3 with von Willbrand Factor (Homo sapiens)
Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)
Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Homo sapiens)
Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)
Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)
Syndecan-1 binds integrin alphaVbeta3 (Homo sapiens)
Dentin matrix protein 1 binds integrin alphaVbeta3 (Homo sapiens)
as a member of
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
LAP3-binding integrins [plasma membrane] (Homo sapiens)
LAP1 binding-integrins [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Integrin alphaVBeta1,3,5 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alpha3beta1 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 [plasma membrane] (Homo sapiens)
Integrins [plasma membrane] (Homo sapiens)
Fibrilin-binding integrins [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
This entity regulates
Positively
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow
(Homo sapiens)
Inferred To
Integrin alphaVbeta3 [plasma membrane]
(Bos taurus)
Integrin alphaVbeta3 [plasma membrane]
(Caenorhabditis elegans)
Integrin alphaVbeta3 [plasma membrane]
(Canis familiaris)
Integrin alphaVbeta3 [plasma membrane]
(Danio rerio)
Integrin alphaVbeta3 [plasma membrane]
(Drosophila melanogaster)
Integrin alphaVbeta3 [plasma membrane]
(Gallus gallus)
Integrin alphaVbeta3 [plasma membrane]
(Mus musculus)
Integrin alphaVbeta3 [plasma membrane]
(Rattus norvegicus)
Integrin alphaVbeta3 [plasma membrane]
(Sus scrofa)
Integrin alphaVbeta3 [plasma membrane]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-1795
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