Interaction of DAP12 and MDL-1

Stable Identifier
R-HSA-210271
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Myeloid DAP12-associating lectin (MDL)-1, also designated CLEC5A, is a type II transmembrane protein belonging to the C-type lectin superfamily and expressed exclusively in monocytes and macrophages. MDL-1 contains a charged residue in the transmembrane region and this enables it to pair with DAP12 dimers. MDL-1's natural mammalian ligand is unknown, but MDL-1 is a receptor for Dengue virus CLEC5A is critical for dengue-virus-induced lethal disease (Chen et al 2008). Engagement with DAP12 has been shown to regulate osteoclastogenesis and myeloid cell-associated inflammatory responses (Bakker et al. 1999, Aoki et al. 2009, Inui et al 2009, Joyce-Shaikh et al. 2010, Cheung et al. 2011).

Literature References
PubMed ID Title Journal Year
10449773 Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells

Bakker, AB, Baker, E, Sutherland, GR, Phillips, JH, Lanier, LL

Proc Natl Acad Sci U S A 1999
15884055 KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions

Tomasello, E, Vivier, E

Eur J Immunol 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed