Interaction of PECAM-1 and SHP-1

Stable Identifier
R-HSA-210277
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain of PECAM-1 is required for the downstream signalling events observed following PECAM-1 ligation. Both SH2 domains of SHP-1 are required in tandem to bind PECAM-1.

Participants
Participant Of