Reactome: A Curated Pathway Database

Trans-homophilic interaction of PECAM-1

Stable Identifier
R-HSA-210285
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PECAM-mediated adhesion is complex, because it is capable of binding both to itself (homophilic adhesion) and to non-PECAM ligands (heterophilic adhesion). The trans-homophilic interaction between the two PECAM-1 molecules is mediated by their NH2-terminal membrane distal Ig homology domains 1 and 2 plus the proper spacing formed by the six Ig-homology domains.

Literature References
Participants
Participant Of