Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src

Stable Identifier
R-HSA-210291
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]
Physical Entity
Activity