Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src

Stable Identifier
R-HSA-210291
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

PECAM-1 is capable of transmitting information into the cell following its engagement and becomes tyrosine-phosphorylated during the platelet aggregation process. The Src family of tyrosine kinases (more specifically, Src, Lyn, and c-src) has been widely implicated in the phosphorylation of PECAM-1. Conserved tyrosine residues (Tyr663 and Tyr686) within the PECAM-1 cytoplasmic ITIM motif have been shown to become phosphorylated. Tyrosine phosphorylation of PECAM-1 prompts its association with intracellular signal transduction molecules.

Literature References
PubMed ID Title Journal Year
10858437 Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.

Cicmil, M, Thomas, JM, Sage, T, Barry, FA, Leduc, M, Bon, C, Gibbins, JM

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src family tyrosine kinases (SFKs) [cytosol]
Physical Entity
Activity
Authored
Reviewed