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Interaction of DAP12 and TREM1
Stable Identifier
R-HSA-210292
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DAP12 interactions (Homo sapiens)
Interaction of DAP12 and TREM1 (Homo sapiens)
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TREM proteins (triggering receptors expressed on myeloid cells) are a family of cell surface receptors involved in innate immune responses. They are expressed in myeloid cells and have both positive and negative functions in regulating myeloid cell activation and differentiation. Humans have two members, TREM1 and TREM2. TREM1 is considered an amplifier of the immune response, while TREM2 is believed to be a negative regulator of inflammatory responses (Sharif & Knaap 2008). TREM proteins consist of a single extracellular V-type Ig-like domain, a transmembrane region and a short cytoplasmic tail lacking any signalling motifs (Kelker et al. 2004). Both receptors associate with DAP12 for signalling.
The ligand for TREM1 is unknown. TREM1 associates with DAP12 dimer. This interaction is mediated by aspartic acid and adjacent threonine residues in the DAP12 dimer that interface with lysine residues in the TREM1 transmembrane region. TREM1 engagement triggers the production of inflammatory chemokines and cytokines such as IL-8 and myeloperoxidase (MPO) in neutrophils and IL-8, MCP-1, and TNF in monocytes (Tessarz & Cerwenka 2008, Bouchon et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
17110943
The TREM receptor family and signal integration
Klesney-Tait, J
,
Colonna, M
,
Turnbull, IR
Nat Immunol
2006
15884055
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
Vivier, E
,
Tomasello, E
Eur J Immunol
2005
12776204
TREMs in the immune system and beyond
Colonna, M
Nat Rev Immunol
2003
Participants
Input
DAP12 dimer [plasma membrane]
(Homo sapiens)
TREM1 [plasma membrane]
(Homo sapiens)
Output
DAP12 dimer:TREM1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
DAP12 interactions (Homo sapiens)
Orthologous Events
Interaction of DAP12 and TREM1 (Canis familiaris)
Interaction of DAP12 and TREM1 (Mus musculus)
Interaction of DAP12 and TREM1 (Rattus norvegicus)
Interaction of DAP12 and TREM1 (Sus scrofa)
Authored
Garapati, P V (2012-05-25)
Reviewed
Lanier, LL (2012-08-09)
Created
Garapati, P V (2008-01-10)
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