Interaction of integrin alphaVbeta3 with PECAM1

Stable Identifier
R-HSA-210304
Type
Reaction [binding]
Species
Homo sapiens
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Alpha v beta 3 integrin is one of the potential heterophilic ligands of PECAM-1 that is involved in down-regulation of T-cell responses. The heterophilic interaction of alpha v beta 3 integrin on endothelial cells with PEACAM-1 on leukocytes increases the adhesive function of beta integrins on T cells, monocytes, neutrophils and NK cells suggesting that leukocyte PEACAM-1 act as a signaling molecule.

Literature References
PubMed ID Title Journal Year
8838667 Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1

Buckley, CD, Doyonnas, R, Newton, JP, Blystone, SD, Brown, EJ, Watt, SM, Simmons, DL

J Cell Sci 1996
7542249 CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium

Piali, L, Hammel, P, Uherek, C, Bachmann, F, Gisler, RH, Dunon, D, Imhof, BA

J Cell Biol 1995
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