Interaction of DAP12 and KIR2DS2

Stable Identifier
R-HSA-210309
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Killer cell immunoglobulin-like two-domain short-tail receptor 2 (KIR2DS2) is an activating KIR receptor invariably expressed on the cell surface of NK cells and subsets of T cells. The ligand specificity of KIR2DS2 is unknown; it does not bind the HLA-Cw3 molecules recognised by the inhibitory receptor KIR2DL2, despite 99% extracellular amino acid identity (Saulquin et al. 2003). In the presence of DAP12, cross-linking of KIR2DS2 with monoclonal antibody leads to phosphorylation of JNK and ERK and activation of both cytotoxicity and IFN-production.

Literature References
PubMed ID Title Journal Year
12668644 Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)

Saulquin, X, Gastinel, LN, Vivier, E

J Exp Med 2003
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