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SLC1A2 [plasma membrane]
Stable Identifier
R-HSA-210459
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EAAT2
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A2 [plasma membrane] (Homo sapiens)
Neurotransmitter uptake and metabolism In glial cells (Homo sapiens)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Homo sapiens)
glutamate uptake by astrocytes (Homo sapiens)
Astrocytic EAATs [plasma membrane] (Homo sapiens)
SLC1A2 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43004 SLC1A2
Gene Names
SLC1A2, EAAT2, GLT1
Chain
chain:1-574
Reference Genes
BioGPS Gene:6506 SLC1A2
COSMIC (genes):SLC1A2 SLC1A2
CTD Gene:6506 SLC1A2
dbSNP Gene:6506 SLC1A2
ENSEMBL:ENSG00000110436 SLC1A2
ENSEMBL_homo_sapiens_GENE:ENSG00000110436.13 SLC1A2
HGNC:10940 SLC1A2
KEGG Gene (Homo sapiens):6506 SLC1A2
Monarch:6506 SLC1A2
NCBI Gene:6506 SLC1A2
OMIM:600300 SLC1A2
UCSC:P43004 SLC1A2
Reference Transcript
RefSeq:NM_001195728.2 SLC1A2
RefSeq:NM_001252652.1 SLC1A2
RefSeq:NM_004171.3 SLC1A2
Other Identifiers
11718492_at
11718493_a_at
11718494_at
11745115_a_at
1558009_PM_at
1558009_at
1558010_PM_s_at
1558010_s_at
16737325
208389_PM_s_at
208389_s_at
225491_PM_at
225491_at
3369369
3369370
3369371
3369372
3369373
3369377
3369378
3369379
3369383
3369384
3369389
3369392
3369394
3369397
3369398
3369399
3369404
3369405
3369417
3369426
3369427
3369428
3369429
3369430
3369431
34582_at
45647_s_at
6506
7947496
90238_at
A_23_P162068
A_24_P350759
GE54848
GE56822
GE58848
GO:0003013
GO:0005215
GO:0005313
GO:0005314
GO:0005515
GO:0005886
GO:0006575
GO:0006750
GO:0006790
GO:0006811
GO:0006836
GO:0006865
GO:0007268
GO:0007399
GO:0007632
GO:0008509
GO:0009410
GO:0009416
GO:0009611
GO:0009986
GO:0015175
GO:0015179
GO:0015293
GO:0015501
GO:0015804
GO:0015813
GO:0016020
GO:0021537
GO:0023052
GO:0030424
GO:0030534
GO:0030673
GO:0031668
GO:0031982
GO:0033229
GO:0035264
GO:0042734
GO:0043200
GO:0043226
GO:0044297
GO:0044306
GO:0045121
GO:0045202
GO:0046326
GO:0046872
GO:0048856
GO:0055085
GO:0065003
GO:0070207
GO:0070633
GO:0070778
GO:0070779
GO:0071314
GO:0097449
GO:0098656
GO:0098712
GO:0098796
GO:0098810
GO:0098978
GO:0140009
GO:0150104
GO:1902475
GO:1903712
HMNXSV003007377
Hs.4774.0.A1_3p_at
Hs2.349088.1.S1_3p_s_at
ILMN_1785380
PH_hs_0023922
TC11001551.hg
U01824_at
g4759123_3p_a_at
Participates
as a member of
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
as a candidate of
Astrocytic EAATs [plasma membrane] (Homo sapiens)
Inferred To
Eaat2 [plasma membrane]
(Drosophila melanogaster)
SLC1A2 [plasma membrane]
(Bos taurus)
SLC1A2 [plasma membrane]
(Canis familiaris)
SLC1A2 [plasma membrane]
(Danio rerio)
SLC1A2 [plasma membrane]
(Gallus gallus)
SLC1A2 [plasma membrane]
(Mus musculus)
SLC1A2 [plasma membrane]
(Rattus norvegicus)
SLC1A2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004162.2
,
NP_001239581.1
,
NP_001182657.1
Guide to Pharmacology - Targets
869
OpenTargets
ENSG00000110436
ZINC - Substances
EAA2_HUMAN
ZINC target
P43004
ZINC - Biogenic
EAA2_HUMAN
PRO
P43004
PDB
7VR7
,
7XR4
,
7XR6
,
7VR8
ZINC - Metabolites
EAA2_HUMAN
GeneCards
P43004
HPA
ENSG00000110436-SLC1A2
Ensembl
ENSP00000494828
,
ENSP00000493945
,
ENSP00000379102
,
ENST00000644299
,
ENST00000278379
,
ENST00000643000
,
ENSP00000494669
,
ENSP00000494025
,
ENSP00000278379
,
ENSP00000496123
,
ENST00000395753
,
ENSG00000110436
,
ENST00000645194
,
ENSP00000496093
,
ENSP00000495164
,
ENST00000644050
,
ENST00000643305
,
ENST00000647104
,
ENST00000645634
Pharos - Targets
P43004
Orphanet
24907
ZINC - Predictions - Purchasable
EAA2_HUMAN
HMDB Protein
HMDBP03147
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.462
4
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