Reactome | STXBP1-1 [cytosol]

STXBP1-1 [cytosol]

Stable Identifier

R-HSA-210514

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MUNC18, STXBP1 isoform 1

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General

Munc 18 interacts with syntaxin in the plasma membrane, with Mint (Munc 18 interacting) which in turn interacts with CASK and neurexins. Munc18 also interacts with granulophilin. Granulophilin is interacts simultaneously with syntaxin and Munc18. These interactions are believed to be involved in the docking of the synaptic vesicle to the plasma membrane. However, the sequence of events is unclear.

Literature References

PubMed ID	Title	Journal	Year
11010978	Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. Turner, RS, Borg, JP, Margolis, B, Mueller, HT	J Biol Chem	2000

External Reference Information

External Reference

UniProt:P61764-1 STXBP1

Gene Names

STXBP1, UNC18A

Other Identifiers

11729699_a_at

11729700_a_at

11729701_x_at

11746786_a_at

17089371

202260_PM_s_at

202260_s_at

3189933

3189934

3189935

3189940

3189942

3189943

3189944

3189946

3189947

3189948

3189949

3189951

3189952

3189953

3189954

3189955

3189957

3189958

3189959

3189960

3189961

3189962

3189963

3189964

3189965

3189967

3189968

3189969

3189970

3189971

3189972

3189973

3189975

33942_s_at

58037_at

6812

8158059

A_23_P135310

A_24_P201171

D63851_at

GE79675

GE884977

GO:0000149

GO:0002576

GO:0003006

GO:0003723

GO:0005515

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006886

GO:0006887

GO:0006904

GO:0007155

GO:0007269

GO:0007274

GO:0007412

GO:0010807

GO:0012501

GO:0015031

GO:0016020

GO:0016082

GO:0016188

GO:0016192

GO:0017075

GO:0019901

GO:0019904

GO:0019905

GO:0022414

GO:0023052

GO:0030141

GO:0030424

GO:0031091

GO:0031333

GO:0031338

GO:0031410

GO:0031630

GO:0032229

GO:0032355

GO:0032991

GO:0035493

GO:0035542

GO:0042802

GO:0043226

GO:0043274

GO:0043306

GO:0043524

GO:0045335

GO:0045921

GO:0045956

GO:0048471

GO:0050821

GO:0051402

GO:0051649

GO:0060292

GO:0065003

GO:0070062

GO:0070527

GO:0071346

GO:0072659

GO:0098688

GO:0098793

GO:0098794

GO:0098831

GO:0098888

GO:0098978

GO:0099523

GO:0106022

GO:1903296

GO:2000367

HMNXSV003011439

ILMN_1728747

ILMN_1810657

ILMN_2414878

PH_hs_0023811

TC09000668.hg

g4507296_3p_a_at

Participates

as an input of

as an output of

as a component of

Inferred To

SEC1 [cytosol] (Saccharomyces cerevisiae)

unc-18 [cytosol] (Caenorhabditis elegans)

STXBP1 [cytosol] (Bos taurus)

STXBP1 [cytosol] (Canis familiaris)

STXBP1 [cytosol] (Gallus gallus)

STXBP1 [cytosol] (Sus scrofa)

sec1 [cytosol] (Dictyostelium discoideum)

sec1 [cytosol] (Schizosaccharomyces pombe)

Rop [cytosol] (Drosophila melanogaster)

Stxbp1 [cytosol] (Mus musculus)

Stxbp1 [cytosol] (Rattus norvegicus)

STXBP1-1 [cytosol] (Plasmodium falciparum)

stxbp1 [cytosol] (Xenopus tropicalis)

stxbp1b [cytosol] (Danio rerio)

Cross References

RefSeq

NP_003156.1, NP_001027392.1

ENSEMBL

ENST00000373299, ENSP00000362399, ENST00000373302, ENSP00000362396

OpenTargets

ENSG00000136854

HPA

ENSG00000136854-STXBP1

PRO

P61764

Pharos - Targets

P61764

GlyGen

P61764

Orphanet

STXBP1

HMDB Protein

HMDBP08589

PDB

6L03

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4C7 STX19			0.85	11
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.805	9
UniProt:O75558 STX11			0.782	8
UniProt:Q13190 STX5	5	STX5 [cytosol] (R-HSA-9613991) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [endoplasmic reticulum membrane] (R-HSA-5689474)	0.718	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P21917 DRD4	1	DRD4 [plasma membrane] (R-HSA-390809)	0.556	3
UniProt:Q6IPU0 CENPP	2	CENPP [nucleoplasm] (R-HSA-606341) CENPP [cytosol] (R-HSA-375299)	0.556	3
IntAct:EBI-25911596 CCSB			0.556	3
UniProt:Q8N0Z3 SPICE			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q96C24 SYTL4	2	SYTL4 [plasma membrane] (R-HSA-8862971) SYTL4 [platelet alpha granule membrane] (R-HSA-8862959)	0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q0VDD7 BRME1			0.556	3
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.556	3
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [plasma membrane] (R-HSA-2029017)	0.527	2
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.527	4
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.499	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.463	10

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