Reactome | PTPN1 [cytosol]

PTPN1 [cytosol]

Stable Identifier

R-HSA-210625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PTP1B, Protein-tyrosine phosphatase 1B

Locations in the PathwayBrowser for interactor UniProt:P02730 SLC4A1

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External Reference Information

External Reference

UniProt:P18031 PTPN1

Gene Names

PTPN1, PTP1B

Chain

chain:1-435

Reference Genes

BioGPS Gene:5770 PTPN1

COSMIC (genes):PTPN1 PTPN1

CTD Gene:5770 PTPN1

dbSNP Gene:5770 PTPN1

ENSEMBL:ENSG00000196396 PTPN1

HGNC:9642 PTPN1

KEGG Gene (Homo sapiens):5770 PTPN1

Monarch:5770 PTPN1

NCBI Gene:5770 PTPN1

OMIM:176885 PTPN1

UCSC:P18031 PTPN1

Reference Transcript

Other Identifiers

0000730348

11717146_at

11717147_a_at

16914844

16914859

202716_at

3888722

3888723

3888724

3888725

3888747

3888751

3888753

3888755

3888761

3888762

3888764

3888766

3888767

3888769

3888770

3888772

3888773

3888774

3888775

3888776

3888777

3888778

3888783

3888785

40137_at

5770

588_at

591_s_at

8063394

A_14_P115470

A_23_P338890

GE57927

GO:0002376

GO:0003674

GO:0003723

GO:0004721

GO:0004725

GO:0005158

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005759

GO:0005768

GO:0005769

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006464

GO:0006470

GO:0006810

GO:0006950

GO:0007010

GO:0007165

GO:0007257

GO:0008150

GO:0008219

GO:0008270

GO:0008286

GO:0009056

GO:0009966

GO:0009968

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0016311

GO:0016787

GO:0016791

GO:0019899

GO:0019901

GO:0030061

GO:0030100

GO:0030948

GO:0030968

GO:0030971

GO:0031410

GO:0031532

GO:0032991

GO:0033157

GO:0034620

GO:0034976

GO:0035335

GO:0035791

GO:0036498

GO:0043167

GO:0043226

GO:0043407

GO:0045296

GO:0046626

GO:0046627

GO:0046875

GO:0051721

GO:0060338

GO:0060397

GO:0061098

GO:0070373

GO:0097443

GO:0098554

GO:1902202

GO:1902236

GO:1903896

GO:1903898

GO:1990264

GO:2000646

ILMN_1681591

ILMN_3310291

M31724_at

M33684_s_at

PH_hs_0025079

TC20000403.hg

TC20000405.hg

g4506288_3p_at

Participant Of

hasComponent

input

hasMember

output

Inferred To

ptpn1 [cytosol] (Danio rerio)

ptpn1 [cytosol] (Xenopus tropicalis)

Ptpn1 [cytosol] (Mus musculus)

Ptpn1 [cytosol] (Rattus norvegicus)

PTPN1 [cytosol] (Bos taurus)

PTPN1 [cytosol] (Canis familiaris)

PTPN1 [cytosol] (Sus scrofa)

Ptp61F [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002818.1, NP_001265547.1

ZINC - World Drugs

PTN1_HUMAN

OpenTargets

ENSG00000196396

ZINC - FDA approved

PTN1_HUMAN

ZINC - Substances

PTN1_HUMAN

ZINC target

P18031

ZINC - Biogenic

PTN1_HUMAN

PRO

P18031

PDB

1OEV, 5QG0, 5QG8, 1I57, 5KA7, 5QFA, 5K9W, 5QF5, 1LQF, 5QEK, 2CMC, 5KAD, 2CMA, 2HNQ, 1PTT, 5QFD, 5QFL, 1OES, 5QG3, 3ZV2, 1A5Y, 6PHS, 2ZN7, 1PYN, 6PM8, 6OLQ, 5QDN, 1BZH, 2CNG, 6B8E, 5QFS, 2VEW, 5QEN, 5QFV, 2H4G, 5QF0, 4QAH, 2QBR, 1T48, 3D9C, 5QDR, 5QDZ, 2F6F, 1C88, 5QEI, 3QKP, 1KAV, 1C83, 5QFJ, 1Q6J, 5QDK, 5QGE, 5QEL, 6B8Z, 1NL9, 5QEC, 1T49, 6CWV, 5KA3, 1NWL, 5QDO, 6NTP, 2VEX, 1C86, 5QEG, 1GFY, 5QEX, 2VEU, 3A5K, 5QF8, 5KA0, 1Q6T, 1Q6N, 2BGE, 5QDH, 2AZR, 5QE2, 5QFG, 2QBP, 5QF3, 2FJN, 1BZC, 1PTV, 5QET, 1ECV, 5KA4, 5QF4, 2CNH, 5K9V, 2F6V, 5QEW, 5QG2, 5QFK, 5QFC, 5QF7, 5QE6, 3EAX, 2CNF, 1G7G, 4ZRT, 2QBQ, 2NT7, 5QDQ, 5QFU, 5QFX, 1T4J, 5KA9, 1ONY, 5QFP, 1OEU, 6B95, 5QE4, 5QFI, 2CNI, 1KAK, 5KAC, 6CWU, 5KA2, 3ZMP, 2ZMM, 5QFN, 5QEF, 4BJO, 5QDE, 4QBW, 1G1G, 5QEQ, 5QGB, 5QDY, 1Q6S, 6PG0, 3SME, 2F6Z, 2BGD, 5QE1, 5QEH, 1Q1M, 1NO6, 5QF2, 2HB1, 5QDT, 1AAX, 5QFZ, 5QEB, 2FJM, 3EU0, 1PXH, 1QXK, 2F6T, 5QDM, 1EEO, 2B4S, 5QFR, 2H4K, 1WAX, 4QAP, 5QEE, 3CWE, 2QBS, 5QE5, 1PA1, 5QDG, 5QF6, 1PTU, 5QEZ, 2CM8, 1BZJ, 1C84, 5QFO, 2F71, 5QG7, 6PHA, 1PTY, 5KA8, 5QDJ, 3A5J, 5QES, 2F6W, 1OEO, 5QFW, 5QE3, 2CM3, 5QDV, 6PFW, 1C85, 5QEV, 5T19, 6OMY, 6BAI, 5QFF, 5QFM, 5QG5, 1NWE, 1G1F, 2B07, 5QEP, 5QE9, 5QGA, 2F6Y, 3I80, 6B8X, 1PH0, 5QDS, 4QBE, 5QGD, 1NZ7, 5QFB, 5QFQ, 1L8G, 5QEA, 4I8N, 5QG1, 5QG9, 5QDL, 1EEN, 5QFY, 5QFT, 5QED, 1OET, 1G7F, 5QDF, 5QDW, 5QEO, 2CMB, 5KAA, 6PGT, 5QE7, 5QE0, 5QEY, 1SUG, 2CNE, 5QF1, 1NNY, 5QG6, 3QKQ, 5QDI, 5QEJ, 1OEM, 2CM7, 1Q6M, 1C87, 4Y14, 5QEU, 5QDU, 5QEM, 2CM2, 5QGF, 3EB1, 2NTA, 3ZMQ, 2VEY, 1G1H, 5KAB, 5QDP, 2HNP, 5QDX, 6OLV, 5QG4, 6B8T, 5QFE, 5KA1, 5QF9, 3I7Z, 5QE8, 1ONZ, 2VEV, 5QFH, 2F70, 1JF7, 5QGC, 5QER, 6B90, 1XBO, 1Q6P

ZINC - Investigational

PTN1_HUMAN

ZINC - Metabolites

PTN1_HUMAN

HPA

ENSG00000196396-PTPN1

GeneCards

P18031

Ensembl

ENSG00000196396, ENSP00000360683, ENST00000371621

ZINC - Predictions - Purchasable

PTN1_HUMAN

HMDB Protein

HMDBP08931

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.979	32
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.937	14
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.864	8
UniProt:O60674 JAK2	8	p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327) p-JAK2 [cytosol] (R-HSA-210621) p-Y813-JAK2 [cytosol] (R-HSA-997248) JAK2 V617F [nucleoplasm] (R-HSA-5211269) JAK2 [endosome lumen] (R-HSA-2002372) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799)	0.819	5
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.786	5
UniProt:Q61140 Bcar1	6	p-12Y-P130Cas [cytosol] (R-MMU-5218727) phospho-Bcar1 [cytosol] (R-MMU-372645) Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743)	0.756	5
UniProt:Q9H1D0 TRPV6	1	TRPV6 [plasma membrane] (R-HSA-937289)	0.744	6
UniProt:P08581 MET	7	p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.713	3
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.713	3
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.702	3
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [Golgi membrane] (R-HSA-204504)	0.697	5
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367)	0.676	4
UniProt:P05622	3	Pdgfrb [plasma membrane] (R-MMU-186767) phospho-Pdgfrb [plasma membrane] (R-MMU-8864039) phospho-Pdgfrb [plasma membrane] (R-MMU-186803)	0.656	3
UniProt:Q96TC7 RMD3			0.646	4
UniProt:P10912 GHR	7	GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.645	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.642	4
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.623	2
ChEBI:17440 4-NITROPHENYL DIHYDROGEN PHOSPHATE			0.623	2
UniProt:P11274-1 BCR			0.602	3
UniProt:P19235 EPOR	2	p-8Y-EPOR [plasma membrane] (R-HSA-9006274) EPOR [plasma membrane] (R-HSA-1168347)	0.602	3
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-5218739) phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625)	0.591	5
UniProt:O43561 LAT	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.591	3
UniProt:Q63768 Crk	2	Crk [cytosol] (R-RNO-2980677) Crk [cytosol] (R-RNO-110017)	0.589	2
UniProt:P62994 Grb2	3	Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) Grb2 [cytosol] (R-RNO-74686)	0.589	3
UniProt:Q9WUD9 Src	11	phospho-Src [cytosol] (R-RNO-8964276) Src [cytosol] (R-RNO-9628701) MyrG,p-Y419-Src [plasma membrane] (R-RNO-9037057) MyrG-p-Y419-Src [plasma membrane] (R-RNO-8937901) Src [plasma membrane] (R-RNO-8876922) SRC_RAT [cytosol] (R-RNO-548926) phospho-Src [cytosol] (R-RNO-377592) phospho-Src [plasma membrane] (R-RNO-1810408) phospho-Src [plasma membrane] (R-RNO-377598) Src [plasma membrane] (R-RNO-65043) phospho-Src [plasma membrane] (R-RNO-112331)	0.564	2
UniProt:P42229 STAT5A	5	p-Y649-STAT5A [cytosol] (R-HSA-8980151) p-STAT5A [nucleoplasm] (R-HSA-8982836) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.558	2
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:P10686 Plcg1	8	phospho-Plcg1 [plasma membrane] (R-RNO-1169084) p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) Plcg1 [plasma membrane] (R-RNO-182093) Plcg1 [plasma membrane] (R-RNO-167682) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [cytosol] (R-RNO-202320) phospho-Plcg1 [cytosol] (R-RNO-202357) phospho-Plcg1 [plasma membrane] (R-RNO-167679)	0.556	4
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q96HV5 TM41A			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:P57054 PIGP	1	PIGP(26-158) [endoplasmic reticulum membrane] (R-HSA-162761)	0.556	3
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	3
UniProt:P35570 Irs1	7	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.525	3
UniProt:P15116	3	Cdh2 [endoplasmic reticulum lumen] (R-MMU-8956761) phospho-Cdh2 [endoplasmic reticulum lumen] (R-MMU-8956899) Cdh2 [plasma membrane] (R-MMU-191429)	0.524	3
UniProt:P02730 SLC4A1	8	SLC4A1 G701D [plasma membrane] (R-HSA-5657836) SLC4A1 R589H [plasma membrane] (R-HSA-5657833) SLC4A1 [plasma membrane] (R-HSA-420408) SLC4A1 V850del [plasma membrane] (R-HSA-5657828) SLC4A1 V488M [plasma membrane] (R-HSA-5657845) SLC4A1 R589C [plasma membrane] (R-HSA-5657843) SLC4A1 S613F [plasma membrane] (R-HSA-5657854) SLC4A1 E90K [plasma membrane] (R-HSA-5657855)	0.499	2
UniProt:P05106 ITGB3	3	ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3 [plasma membrane] (R-HSA-57600)	0.499	4

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