HNF6- and FGF10-dependent synthesis of PDX1 protein

Stable Identifier
R-HSA-210769
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HNF6- and FGF10-dependent synthesis of PDX1 protein
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The PDX1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription requires the activities of the HNF6 transcription factor and FGF10. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FGF10 [extracellular region] (Homo sapiens)
Regulator
ONECUT1 [nucleoplasm] (Homo sapiens)
Inferred From
FGF10 activates Pdx1 expression in the developing early pancreatic bud (Mus musculus)
HNF6 transactivates Pdx1 (Mus musculus)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
D'Eustachio, P  (2008-01-16)
Cite Us!