Trans-phosphorylation of Tie2

Stable Identifier
R-HSA-210872
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The dimerization of Tie2 leads to autophosphorylation and activation of its kinase domain. There are multiple tyrosine phosphorylation sites in the Tie2 kinase domain. The phosphorylated tyrosine residues provide the interaction site for the SH2 domains of other downstream signaling molecules like PI3K, Grb2, SHP2 etc.

Literature References
PubMed ID Title Journal Year
14749497 Functional significance of Tie2 signaling in the adult vasculature Recent Prog Horm Res 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of ANGPT1:TEK [plasma membrane]
Physical Entity
Activity
Inferred From