Interaction of SOS-1 to Tie2 bound Grb2

Stable Identifier
R-HSA-210974
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Grb2 binds directly to autophosphorylated Tie2 receptor. GRB2 also contains two SH3 domains, which bring various ligands to the sites of active signaling. One of the SH3 domains on Tie2-bound Grb2 recruits SOS1, an activating nucleotide exchange factor for Ras. This interaction of Sos1 to Grb2 brings Sos1 towards Ras molecules leading to Ras activation. Ras is implicated in the MAP kinase cascade, a pathway in cell growth stimulation, migration and differentiation.

Literature References
PubMed ID Title Journal Year
7478529 GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase

Huang, L, Turck, CW, Rao, P, Peters, KG

Oncogene 1995
11191051 Tek/Tie2 signaling: new and old partners

Jones, N, Dumont, DJ

Cancer Metastasis Rev 2000
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