Reactome: A Curated Pathway Database

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)

Stable Identifier
R-HSA-210977
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Sos-1 bound to Grb2:Tie2 complex promotes the exchange of inactive Ras-GDP to active Ras-GTP (Boriack-Sjodin et al.1998, Khan et al. 2004).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
Ras guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane] SOS-1 bound to Tie2:Grb2 [plasma membrane] Ras guanyl-nucleotide exchange factor activity (0005088)
Orthologous Events