Tie2 Signaling

Stable Identifier
R-HSA-210993
Type
Pathway
Species
Homo sapiens
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The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.

Literature References
PubMed ID Title Journal Year
9764820 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

Jones, N, Dumont, DJ

Oncogene 1998
11191051 Tek/Tie2 signaling: new and old partners

Jones, N, Dumont, DJ

Cancer Metastasis Rev 2000
11969368 The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development

Ward, NL, Dumont, DJ

Semin Cell Dev Biol 2002
11566266 Angiopoietin and Tie signaling pathways in vascular development

Loughna, S, Sato, TN

Matrix Biol 2001
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