AKT-mediated inactivation of FOXO1A

Stable Identifier
R-HSA-211163
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).

Literature References
PubMed ID Title Journal Year
12228231 Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

Zhang, X, Gan, L, Pan, H, Guo, S, He, X, Olson, ST, Mesecar, A, Adam, S, Unterman, TG

J Biol Chem 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed