The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).
Zhang, X, Gan, L, Pan, H, Guo, S, He, X, Olson, ST, Mesecar, A, Adam, S, Unterman, TG
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