AKT-mediated inactivation of FOXO1A

Stable Identifier
R-HSA-211163
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).

Participants
Participant Of
Orthologous Events
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