Reactome | CASP3(176-277) [nucleoplasm]

CASP3(176-277) [nucleoplasm]

Stable Identifier

R-HSA-211203

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Caspase-3 (small subunit)

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Literature References

PubMed ID	Title	Journal	Year
11931755	Mechanisms of caspase activation and inhibition during apoptosis Shi, Y	Mol Cell	2002

External Reference Information

External Reference

UniProt:P42574 CASP3

Gene Names

CASP3, CPP32

Chain

propeptide:1-9, propeptide:10-28, chain:29-175, chain:176-277

Reference Genes

COSMIC (genes):CASP3 CASP3

ENSEMBL:ENSG00000164305 CASP3

HGNC:1504 CASP3

UCSC:P42574 CASP3

Other Identifiers

11717805_a_at

11719838_a_at

11719839_a_at

16982011

202763_PM_at

202763_at

236729_PM_at

236729_at

2796488

2796489

2796490

2796491

2796492

2796493

2796494

2796495

2796496

2796497

2796498

2796499

2796500

2796502

2796503

2796504

2796505

2796506

2796507

36143_at

76948_at

8103922

836

A_23_P92410

A_33_P3278118

GE58946

GO:0001554

GO:0001666

GO:0001782

GO:0001818

GO:0002020

GO:0002376

GO:0003824

GO:0004175

GO:0004190

GO:0004197

GO:0004861

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0006974

GO:0007413

GO:0007507

GO:0007605

GO:0007611

GO:0008047

GO:0008233

GO:0008234

GO:0008627

GO:0009410

GO:0009411

GO:0009611

GO:0009749

GO:0010038

GO:0010165

GO:0012501

GO:0014069

GO:0014070

GO:0016005

GO:0016241

GO:0016485

GO:0016787

GO:0021766

GO:0022414

GO:0030154

GO:0030163

GO:0030182

GO:0030216

GO:0030218

GO:0030220

GO:0030889

GO:0031264

GO:0031647

GO:0032025

GO:0032355

GO:0032496

GO:0034349

GO:0034612

GO:0035094

GO:0035556

GO:0042542

GO:0043025

GO:0043029

GO:0043065

GO:0043200

GO:0043226

GO:0043525

GO:0044346

GO:0044877

GO:0045165

GO:0045786

GO:0046007

GO:0048011

GO:0048856

GO:0050877

GO:0051146

GO:0051384

GO:0051402

GO:0051604

GO:0061713

GO:0070269

GO:0071407

GO:0071887

GO:0072734

GO:0097153

GO:0097190

GO:0097193

GO:0097194

GO:0097199

GO:0097200

GO:0098693

GO:0098772

GO:0098978

GO:0140096

GO:0140639

GO:1902004

GO:1904019

HMNXSV003052694

Hs.141125.0.A1_3p_at

ILMN_1731639

ILMN_2388155

PH_hs_0022563

TC04001807.hg

U13737_at

g4757911_3p_at

Participates

as a component of

CASP3(29-175):CASP3(176-277) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CASP3(1-277) [cytosol]

CASP3(29-175) [nucleoplasm]

CASP3(29-175) [cytosol]

CASP3(176-277) [cytosol]

Inferred To

Casp3 [nucleoplasm] (Mus musculus)

Casp3 [nucleoplasm] (Rattus norvegicus)

Drice [nucleoplasm] (Drosophila melanogaster)

CASP3(176-277) [nucleoplasm] (Sus scrofa)

ced-3 [nucleoplasm] (Caenorhabditis elegans)

casp3a [nucleoplasm] (Danio rerio)

casp3.2 [nucleoplasm] (Xenopus tropicalis)

CASP3 [nucleoplasm] (Bos taurus)

CASP3 [nucleoplasm] (Canis familiaris)

CASP3 [nucleoplasm] (Gallus gallus)

Cross References

ZINC - World Drugs

CASP3_HUMAN

Guide to Pharmacology - Targets

1619

ENSEMBL

ENSP00000514798, ENSP00000514797, ENST00000700100, ENST00000700101, ENST00000308394, ENST00000523916, ENSP00000311032, ENSP00000428929

OpenTargets

ENSG00000164305

ZINC - FDA approved

CASP3_HUMAN

ZINC - Substances

CASP3_HUMAN

ZINC - Biogenic

CASP3_HUMAN

ZINC target

P42574

PRO

P42574

GlyGen

P42574

ZINC - Investigational

CASP3_HUMAN

IntEnz

3.4.22.56

HPA

ENSG00000164305-CASP3

Pharos - Targets

P42574

ZINC - Predictions - Purchasable

CASP3_HUMAN

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.872	7
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.672	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.659	4
UniProt:O14727 APAF1	4	APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [secretory granule lumen] (R-HSA-6801271) APAF1 [cytosol] (R-HSA-50099)	0.653	7
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.644	3
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.623	2
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.609	2
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.571	2
UniProt:Q9Y243 AKT3	6	p-T305,S472-AKT3 [nucleoplasm] (R-HSA-3009365) p-T305,S472-AKT3 [cytosol] (R-HSA-3009367) p-S472-AKT3 [plasma membrane] (R-HSA-3009363) AKT3 [plasma membrane] (R-HSA-2976006) AKT3 [cytosol] (R-HSA-2976007) p-T305-AKT3 [cytosol] (R-HSA-3009370)	0.571	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.571	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	9

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