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FOXA2 [nucleoplasm]
Stable Identifier
R-HSA-211275
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
FOXOA2
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Gene Transcription (Homo sapiens)
Positive Regulation of CDH1 Gene Transcription (Homo sapiens)
FOXA2 binds CDH1 gene promoter (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
FOXA2:CDH1 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
FOXA2 stimulates CDH1 gene transcription (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
FOXA2:CDH1 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Cell Lineages of the Exocrine Pancreas (Homo sapiens)
Developmental Lineage of Multipotent Pancreatic Progenitor Cells (Homo sapiens)
Definitive endoderm cell produces dorsal foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Definitive endoderm cell produces ventral foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
ventral foregut endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Dorsal foregut endoderm cell produces duodeno-pancreatic endoderm cell (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Duodeno-pancreatic endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Ventral foregut endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
ventral foregut endoderm cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Acinar Cells (Homo sapiens)
Pancreatic pro-acinar cell produces pancreatic acinar cell (Homo sapiens)
pancreatic pro-acinar cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Pancreatic tip progenitor cell produces pancreatic pro-acinar cell (Homo sapiens)
pancreatic pro-acinar cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces pancreatic tip progenitor cell (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Ductal Cells (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces trunk bipotent pancreatic progenitor cell (Homo sapiens)
pancreatic trunk bipotent progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Trunk bipotent pancreatic progenitor cell produces pancreatic ductal cell (Homo sapiens)
pancreatic trunk bipotent progenitor cell (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of axial mesoderm (Homo sapiens)
Expression of FOXA2 in the anterior primitive streak (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Expression of NOTO in axial mesoderm (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Expression of SHH in axial mesoderm (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
Expression of FOXA2 in definitive endoderm (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Expression of GATA4 in definitive endoderm (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in beta cells (Homo sapiens)
FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)
FOXA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y261 FOXA2
Gene Names
FOXA2, HNF3B, TCF3B
Chain
chain:1-457
Reference Genes
BioGPS Gene:3170 Q9Y2612
COSMIC (genes):FOXA2 FOXA2
CTD Gene:3170 Q9Y2612
dbSNP Gene:3170 FOXA2
ENSEMBL:ENSG00000125798 FOXA2
HGNC:5022 Q9Y2612
KEGG:hsa:3170 Q9Y2612
Monarch:3170 Q9Y2612
NCBI Gene:3170 Q9Y2612
OMIM:600288 Q9Y2612
UCSC:Q9Y261 Q9Y2612
Reference Transcript
RefSeq:NM_021784.5 Q9Y2612
RefSeq:NM_153675.3 Q9Y2612
RefSeq:XM_047440133.1 Q9Y2612
Participates
as a protein marker of
pancreatic pro-acinar cell (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
dorsal foregut endoderm cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
ventral foregut endoderm cell (Homo sapiens)
pancreatic trunk bipotent progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
as an input of
SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
FOXA2 binds CDH1 gene promoter (Homo sapiens)
as a component of
p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
FOXA2:CDH1 gene [nucleoplasm] (Homo sapiens)
as an output of
Expression of FOXA2 in definitive endoderm (Homo sapiens)
Expression of FOXA2 in the anterior primitive streak (Homo sapiens)
This entity regulates
Positively
Expression of NOTO in axial mesoderm
(Homo sapiens)
Expression of SHH in axial mesoderm
(Homo sapiens)
FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein
(Homo sapiens)
Inferred To
Homologues of FOXA2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of FOXA2 [nucleoplasm]
(Schizosaccharomyces pombe)
FKH1 [nucleoplasm]
(Saccharomyces cerevisiae)
HCM1 [nucleoplasm]
(Saccharomyces cerevisiae)
pha-4 [nucleoplasm]
(Caenorhabditis elegans)
sep1 [nucleoplasm]
(Schizosaccharomyces pombe)
fkh [nucleoplasm]
(Drosophila melanogaster)
FOXA2 [nucleoplasm]
(Bos taurus)
FOXA2 [nucleoplasm]
(Canis familiaris)
FOXA2 [nucleoplasm]
(Gallus gallus)
FOXA2 [nucleoplasm]
(Sus scrofa)
foxa2 [nucleoplasm]
(Danio rerio)
mei4 [nucleoplasm]
(Schizosaccharomyces pombe)
Foxa2 [nucleoplasm]
(Mus musculus)
Foxa2 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_047296089.1
,
NP_068556.2
,
NP_710141.1
ENSEMBL
ENST00000419308
,
ENSP00000400341
,
ENSP00000366319
,
ENSG00000125798
,
ENST00000377115
OpenTargets
ENSG00000125798
GeneCards
FOXA2
HPA
ENSG00000125798-FOXA2
PRO
Q9Y261
Pharos - Targets
Q9Y261
GlyGen
Q9Y261
Orphanet
FOXA2
PDB
7YZE
,
7YZF
,
5X07
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