MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein

Stable Identifier
R-HSA-211289
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The INS1 gene, encoding insulin precursor protein, is transcribed and its mRNA is translated on membrane-associated ribosomes. INS1 transcription is positively regulated by the activities of the MAFA, NKX2-2, PAX6, and PDX1 transcription factors. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.

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