CYP4F2, 4F3 20-hydroxylate LTB4

Stable Identifier
R-HSA-211873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
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Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).

Literature References
PubMed ID Title Journal Year
9539102 Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization

Kikuta, Y, Kato, M, Yamashita, Y, Miyauchi, Y, Tanaka, K, Kamada, N, Kusunose, M

DNA Cell Biol 1998
9799565 Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4

Jin, R, Koop, DR, Raucy, JL, Lasker, JM

Arch Biochem Biophys 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
leukotriene-B4 20-monooxygenase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created