Coumarin is 7-hydroxylated by CYP2A13

Stable Identifier
R-HSA-211881
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.

Literature References
PubMed ID Title Journal Year
15196988 Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation

He, XY, Shen, J, Hu, WY, Ding, X, Lu, AY, Hong, JY

Arch Biochem Biophys 2004
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hasEvent
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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