CYP4F12 18-hydroxylates ARA

Stable Identifier
R-HSA-211904
Type
Reaction
Species
Homo sapiens
Compartment
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Human CYP4F12 is involved in metabolism of endogenous compounds such as inflammatory mediators (arachidonic acid and prostaglandin H2) as well as xenobiotics like terfenadine (an antihistaminic drug) (Bylund et al. 2001). The omega-hydroxylation of arachidonic acid (ARA) is shown here to form 18-hydroxyarachidonic acid (18OH-ARA aka 18-HETE).

Literature References
PubMed ID Title Journal Year
11162607 cDna cloning and expression of CYP4F12, a novel human cytochrome P450

Bylund, J, Bylund, M, Oliw, EH

Biochem Biophys Res Commun 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created
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