CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation

Stable Identifier
R-HSA-211910
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.

Literature References
PubMed ID Title Journal Year
9842986 Human liver microsomal metabolism of paclitaxel and drug interactions

Desai, PB, Duan, JZ, Zhu, YW, Kouzi, S

Eur J Drug Metab Pharmacokinet 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created