CYP2C19 5-hydroxylates omeprazole

Stable Identifier
R-HSA-211929
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.

Literature References
PubMed ID Title Journal Year
8647857 Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity

Ibeanu, GC, Ghanayem, BI, Linko, P, Li, L, Pederson, LG, Goldstein, JA

J Biol Chem 1996
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created