CYP3A4 can N-demethylate loperamide

Stable Identifier
R-HSA-211948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The CYP3A family are the most abundantly expressed P450s in human liver, accounting for around 50% of xenobiotic drug metabolism. CYP3A4 is the most abundant member of the family and possesses broad specificity to a range of xenobiotics. Loperamide (LOP), an antidiarrheal, is mainly metabolized to desmethylloperamide (DLOP) through the N-demethylation pathway. This initial N-demethylation is carried out by CYP3A4.

Literature References
PubMed ID Title Journal Year
15365656 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes

Kim, KA, Chung, J, Jung, DH, Park, JY

Eur J Clin Pharmacol 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created