CYP1B1 4-hydroxylates EST17b

Stable Identifier
R-HSA-211951
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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CYP1B1 4-hydroxylates EST17b
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Cytochrome P450 1B1 (CYP1B1) can oxidise a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics as well as activating a range of procarcinogens. A specific substrate is the female sex hormone estradiol-17beta (EST17b) which is 4-hydroxylated to 4-hydroxyestradiol-17beta 4OH-EST17b) (Badawi et al. 2001).

Literature References
PubMed ID Title Journal Year
11555828 Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol

Badawi, AF, Cavalieri, EL, Rogan, EG

Metabolism 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP1B1 [endoplasmic reticulum membrane]
Physical Entity
CYP1B1 [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
This event is regulated
Negatively by
Positively by
Orthologous Events
CYP1B1 4-hydroxylates EST17b (Bos taurus)
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
CYP1B1 4-hydroxylates EST17b (Danio rerio)
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
CYP1B1 4-hydroxylates EST17b (Mus musculus)
CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
CYP1B1 4-hydroxylates EST17b (Sus scrofa)
CYP1B1 4-hydroxylates EST17b (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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