Miscellaneous substrates

Stable Identifier
R-HSA-211958
Type
Pathway
Species
Homo sapiens
Compartment
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Approximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental evidence to know that all these proteins get made and can catalyze CYP-like reactions in vitro, evidence of in vivo function and substrate specificity is insufficient to allow them to be placed in any of the classes in the functional scheme.

Literature References
PubMed ID Title Journal Year
16126164 Function of human cytochrome P450s: characterization of the orphans

Guengerich, FP, Wu, ZL, Bartleson, CJ

Biochem Biophys Res Commun 2005
15102545 57 varieties: the human cytochromes P450

Lewis, DF

Pharmacogenomics 2004
17786643 Characterization of orphan human cytochromes P450

Stark, K, Guengerich, FP

Drug Metab Rev 2007
Participants
Participant Of
Orthologous Events
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