Cyclophosphamide is 4-hydroxylated by CYP2B6

Stable Identifier
R-HSA-211991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.

Literature References
PubMed ID Title Journal Year
12629583 Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation

Xie, HJ, Yasar, U, Lundgren, S, Griskevicius, L, Terelius, Y, Hassan, M, Rane, A

Pharmacogenomics J 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created