CYP2E1 reactions

Stable Identifier
R-HSA-211999
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Homo sapiens
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CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include acetaminophen, benzene, CCl4, halothane, ethanol and vinyl chloride. CYP2E1 contributes to oxidative stress by producing oxidising species called reactive oxygen species (ROS) which can lead to damage to mitochondria, DNA and initiate lipid peroxidation or even cell death.

Literature References
PubMed ID Title Journal Year
14744237 Oxidative stress, toxicology, and pharmacology of CYP2E1

Caro, AA, Cederbaum, AI

Annu Rev Pharmacol Toxicol 2004
15603755 Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1

Gonzalez, FJ

Mutat Res 2005
10397283 Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review

Lieber, CS

Alcohol Clin Exp Res 1999
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