CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

Stable Identifier
R-HSA-212004
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).

Literature References
PubMed ID Title Journal Year
16359177 P450 2C18 catalyzes the metabolic bioactivation of phenytoin

Kinobe, RT, Parkinson, OT, Mitchell, DJ, Gillam, EM

Chem Res Toxicol 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created