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HIST1H2AG [nucleoplasm]
Stable Identifier
R-HSA-212084
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H2A.1
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
Histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)
Histone H2A, HIST1H4 [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC10 deacetylates histone (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
HDAC3 containing complexes deacetylate histone (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
HDAC8 deacetylates histones (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Homo sapiens)
MeR12-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
MeR4-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)
MeR30-histone H2A, Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Activation of Latent HCMV Genome (Homo sapiens)
Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
Core histone octamer [nucleoplasm] (Homo sapiens)
Histone H2A:H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
BRCA1-A Complex:Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
MYSM1 deubiquitinates Histone H2A (Homo sapiens)
MYSM1:EP300:KAT2B:Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
UCH proteinases (Homo sapiens)
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP16,USP21 deubiquitinate Histone H2A (Homo sapiens)
USP16,USP22:Histone H2A [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
USP3,SAGA:Histone H2A,Histone H2B [nucleoplasm] (Homo sapiens)
Histone H2A,Histone H2B [nucleoplasm] (Homo sapiens)
Histone H2A [nucleoplasm] (Homo sapiens)
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
HIST1H2AG [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0C0S8 H2AC11
Gene Names
H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:8329 H2AC11
BioGPS Gene:8330 H2AC11
BioGPS Gene:8332 H2AC11
BioGPS Gene:8336 H2AC11
BioGPS Gene:8969 H2AC11
CTD Gene:8329 H2AC11
CTD Gene:8330 H2AC11
CTD Gene:8332 H2AC11
CTD Gene:8336 H2AC11
CTD Gene:8969 H2AC11
dbSNP Gene:8329 H2AC11
dbSNP Gene:8330 H2AC11
dbSNP Gene:8332 H2AC11
dbSNP Gene:8336 H2AC11
dbSNP Gene:8969 H2AC11
ENSEMBL:ENSG00000196747 HIST1H2AI
ENSEMBL:ENSG00000196787 HIST1H2AG
ENSEMBL:ENSG00000275221 HIST1H2AK
ENSEMBL:ENSG00000276903 HIST1H2AL
ENSEMBL:ENSG00000278677 HIST1H2AM
ENSEMBL_homo_sapiens_GENE:ENSG00000196747.5 H2AC11
ENSEMBL_homo_sapiens_GENE:ENSG00000196787.4 H2AC11
ENSEMBL_homo_sapiens_GENE:ENSG00000275221.2 H2AC11
ENSEMBL_homo_sapiens_GENE:ENSG00000276903.2 H2AC11
ENSEMBL_homo_sapiens_GENE:ENSG00000278677.2 H2AC11
HGNC:4725 H2AC11
HGNC:4726 H2AC11
HGNC:4730 H2AC11
HGNC:4735 H2AC11
HGNC:4737 H2AC11
KEGG Gene (Homo sapiens):8329 H2AC11
KEGG Gene (Homo sapiens):8330 H2AC11
KEGG Gene (Homo sapiens):8332 H2AC11
KEGG Gene (Homo sapiens):8336 H2AC11
KEGG Gene (Homo sapiens):8969 H2AC11
Monarch:8329 H2AC11
Monarch:8330 H2AC11
Monarch:8332 H2AC11
Monarch:8336 H2AC11
Monarch:8969 H2AC11
NCBI Gene:8329 H2AC11
NCBI Gene:8330 H2AC11
NCBI Gene:8332 H2AC11
NCBI Gene:8336 H2AC11
NCBI Gene:8969 H2AC11
OMIM:602787 H2AC11
OMIM:602788 H2AC11
OMIM:602793 H2AC11
OMIM:602796 H2AC11
OMIM:615012 H2AC11
UCSC:P0C0S8 H2AC11
Reference Transcript
RefSeq:NM_003514.2 H2AC11
RefSeq:NM_003511.2 H2AC11
RefSeq:NM_003510.2 H2AC11
RefSeq:NM_021064.4 H2AC11
RefSeq:NM_003509.2 H2AC11
Other Identifiers
11715162_s_at
11715219_s_at
11734234_at
11737572_x_at
11740124_at
11740125_x_at
11759220_at
11759248_at
11759252_at
11759253_x_at
17005858
17005876
17016496
17016512
208583_PM_x_at
208583_x_at
214542_PM_x_at
214542_x_at
214554_PM_at
214554_at
2899757
2899758
2899759
2899760
2900048
2900094
2900095
2900096
2947042
2947043
2947044
2947045
2947065
2947066
2947103
2947104
2947105
31749_f_at
31768_at
33023_at
34156_i_at
34157_f_at
8117580
8117608
8124524
8124540
8329
8330
8332
8336
8969
ADDON002309.hg
ADDON002495.hg
ADDON002786.hg
ADDON002787.hg
ADDON002823.hg
A_14_P122573
A_14_P200168
A_14_P200169
A_21_P0000197
A_23_P168014
A_23_P363174
A_24_P217848
A_24_P303354
A_24_P394510
A_24_P86389
A_32_P221799
A_33_P3360216
GE535482
GE81292
GE81293
GE81294
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0008150
GO:0019899
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0070062
HMNXSV003003032
HMNXSV003020688
HMNXSV003021084
HMNXSV003039464
HMNXSV003050773
Hs.137592.0.S1_3p_at
Hs.137592.0.S1_3p_x_at
Hs.233568.0.S1_3p_at
ILMN_1663453
ILMN_1694699
ILMN_1756022
PH_hs_0007861
PH_hs_0028903
PH_hs_0031765
TC06000223.hg
TC06000269.hg
TC06001425.hg
TC06001430.hg
TC06004063.hg
Z83742_at
Participates
as a member of
Histone HIST1H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
K63polyUb-HIST1H2AG [nucleoplasm]
Ub-HIST1H2AG [nucleoplasm]
Ack6-HIST1H2AG [nucleoplasm]
Me2aR30-HIST1H2AG [nucleoplasm]
MeR30-HIST1H2AG [nucleoplasm]
Me2aR4-HIST1H2AG [nucleoplasm]
MeR4-HIST1H2AG [nucleoplasm]
Me2aR12-HIST1H2AG [nucleoplasm]
MeR12-HIST1H2AG [nucleoplasm]
Ack-HIST1H2AG [nucleoplasm]
Inferred To
LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
H2AC13 [nucleoplasm]
(Canis familiaris)
LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
his-35 [nucleoplasm]
(Caenorhabditis elegans)
HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
H2AC10 [nucleoplasm]
(Bos taurus)
HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
H2Av2 [nucleoplasm]
(Dictyostelium discoideum)
His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
H2AC14 [nucleoplasm]
(Sus scrofa)
his-65 [nucleoplasm]
(Caenorhabditis elegans)
hta2 [nucleoplasm]
(Schizosaccharomyces pombe)
h2ac16 [nucleoplasm]
(Xenopus tropicalis)
HIST1H2AB [nucleoplasm]
(Gallus gallus)
HIST1H2AB [nucleoplasm]
(Plasmodium falciparum)
LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
h2ax1 [nucleoplasm]
(Danio rerio)
Homologues of HIST1H2AB [nucleoplasm]
(Caenorhabditis elegans)
Homologues of HIST1H2AB [nucleoplasm]
(Danio rerio)
Homologues of HIST1H2AB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of HIST1H2AB [nucleoplasm]
(Drosophila melanogaster)
Homologues of HIST1H2AB [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of HIST1H2AB [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of HIST1H2AB [nucleoplasm]
(Xenopus tropicalis)
zgc:56685 [nucleoplasm]
(Danio rerio)
H2AX [nucleoplasm]
(Dictyostelium discoideum)
H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
htas-1 [nucleoplasm]
(Caenorhabditis elegans)
H2Av1 [nucleoplasm]
(Dictyostelium discoideum)
LOC101732059 [nucleoplasm]
(Xenopus tropicalis)
His2A:CG33859 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_066408.1
,
NP_003505.1
,
NP_003501.1
,
NP_003502.1
,
NP_003500.1
OpenTargets
ENSG00000196787
GeneCards
P0C0S8
HPA
ENSG00000196787-H2AC11
,
ENSG00000196747-H2AC13
,
ENSG00000278677-H2AC17
,
ENSG00000275221-H2AC15
,
ENSG00000276903-H2AC16
Ensembl
ENSG00000196747
,
ENST00000618958
,
ENSG00000275221
,
ENST00000613174
,
ENSP00000352119
,
ENSP00000352627
,
ENSP00000482431
,
ENSP00000351589
,
ENSP00000482538
,
ENST00000358739
,
ENSG00000196787
,
ENST00000359611
,
ENSG00000276903
,
ENST00000359193
,
ENSG00000278677
PRO
P0C0S8
Pharos - Targets
P0C0S8
HMDB Protein
HMDBP07725
PDB
7U51
,
7JOA
,
7U50
,
8GUK
,
6X5A
,
8OFF
,
7UV9
,
8ATF
,
8GUJ
,
7JO9
,
7E8D
,
7U53
,
6XJD
,
6R0C
,
7BG9
,
7TAN
,
8GUI
,
5KGF
,
6X59
,
6RNY
,
4QYL
,
7U52
,
8AV6
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.672
21
UniProt:P84233 Unknown
2
Ack15-histone H3.2 [nucleoplasm]
(R-XLA-4549248)
Histone H3.2 [nucleoplasm]
(R-XLA-4549227)
0.65
14
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.65
14
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:P06746 POLB
2
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
POLB [nucleoplasm]
(R-HSA-53845)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
3
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.527
2
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.527
4
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.527
2
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:O95760 IL33
3
IL33 [nucleoplasm]
(R-HSA-6783145)
PolyUb-IL33 [nucleoplasm]
(R-HSA-6783057)
IL33 [extracellular region]
(R-HSA-448567)
0.499
3
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