Reactome | DNMT1 [nucleoplasm]

DNMT1 [nucleoplasm]

Stable Identifier

R-HSA-212181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Icon

Locations in the PathwayBrowser for interactor UniProt:P48552 NRIP1

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA methylation proteins (Homo sapiens)
        
        SUMOyation of DNMT1 with SUMO1 (Homo sapiens)
        
        DNMT1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P26358 DNMT1

Gene Names

DNMT1, AIM, CXXC9, DNMT

Chain

chain:1-1616

Reference Genes

BioGPS Gene:1786 DNMT1

COSMIC (genes):DNMT1 DNMT1

CTD Gene:1786 DNMT1

dbSNP Gene:1786 DNMT1

ENSEMBL:ENSG00000130816 DNMT1

HGNC:2976 DNMT1

Monarch:1786 DNMT1

NCBI Gene:1786 DNMT1

OMIM:126375 DNMT1

UCSC:P26358 DNMT1

Reference Transcript

Other Identifiers

11736405_a_at

11756434_a_at

16868576

1786

201697_PM_s_at

201697_s_at

2968365

37333_at

3850068

3850070

3850071

3850072

3850073

3850074

3850075

3850076

3850077

3850078

3850079

3850080

3850081

3850082

3850083

3850084

3850085

3850086

3850087

3850088

3850089

3850090

3850091

3850092

3850093

3850094

3850095

3850096

3850098

3850099

3850101

3850102

3850103

3850104

3850105

3850107

3850108

3850109

3850110

3850111

3850112

3850113

3850114

3850115

3850116

3850117

3850118

3850119

3850120

3850122

3850123

3850125

3850126

3850127

3850128

3850129

3850132

3850133

3850134

3850135

3850137

3850138

3850139

3850140

3850141

3850142

3850143

3850144

3850151

3850152

3850153

3850155

3850156

3850161

3850168

3850179

7892753

8033912

A_24_P408083

A_33_P3329187

GE59898

GO:0000122

GO:0000792

GO:0001674

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0003886

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005721

GO:0005739

GO:0006325

GO:0006346

GO:0006351

GO:0006355

GO:0008168

GO:0008270

GO:0008327

GO:0009008

GO:0010468

GO:0010628

GO:0010629

GO:0016740

GO:0032259

GO:0042127

GO:0043045

GO:0043073

GO:0043226

GO:0044027

GO:0045892

GO:0046872

GO:0071230

GO:0106222

GO:0140097

GO:0141119

GO:1903926

GO:1904707

GO:1905460

GO:1905931

GO:1990841

HMNXSV003058293

ILMN_1760201

PH_hs_0023014

TC19001159.hg

X63692_at

g4503350_3p_a_at

p33939

Participates

as an input of

as a component of

as a member of

DNMT1,3A,3B [nucleoplasm] (Homo sapiens)

as an output of

Translation of DNMT1 mRNA is repressed by miR-21 (Homo sapiens)

This entity regulates

Negatively

STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)

Other forms of this molecule

monoSUMO1-K-DNMT1 [nucleoplasm]

Inferred To

DNMT1 [nucleoplasm] (Bos taurus)

DNMT1 [nucleoplasm] (Canis familiaris)

DNMT1 [nucleoplasm] (Gallus gallus)

DNMT1 [nucleoplasm] (Mus musculus)

DNMT1 [nucleoplasm] (Rattus norvegicus)

DNMT1 [nucleoplasm] (Sus scrofa)

dnmt1 [nucleoplasm] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

DNMT1_HUMAN

Guide to Pharmacology - Targets

2605

OpenTargets

ENSG00000130816

ENSEMBL

ENSP00000352516, ENSP00000345739, ENST00000359526

ZINC - Substances

DNMT1_HUMAN

ZINC - Biogenic

DNMT1_HUMAN

ZINC target

P26358

PRO

P26358

GlyGen

P26358

PDB

4Z97, 7XIB, 7SFD, 4YOC, 6L1F, 7XI9, 5YDR, 6X9I, 7SFE, 8V9U, 6X9J, 6K3A, 3PTA, 4WXX, 4Z96, 3EPZ, 3SWR, 5WVO, 7SFC, 6X9K, 7SFF, 7SFG

ZINC - Investigational

DNMT1_HUMAN

ZINC - Metabolites

DNMT1_HUMAN

IntEnz

2.1.1.37

HPA

ENSG00000130816-DNMT1

Pharos - Targets

P26358

Orphanet

DNMT1

ZINC - Predictions - Purchasable

DNMT1_HUMAN

HMDB Protein

HMDBP05712

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.752	11
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.74	9
IntAct:EBI-4399559 UBIQ			0.702	3
UniProt:Q96T88 UHRF1	2	UHRF1 [nucleoplasm] (R-HSA-212103) UHRF1 [cytosol] (R-HSA-9818452)	0.696	12
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.693	8
UniProt:Q96JM7 LMBL3			0.674	11
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.643	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.628	8
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.623	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.611	6
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.597	5
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.597	7
UniProt:Q96JK2 DCAF5	1	DCAF5 [nucleoplasm] (R-HSA-8955189)	0.576	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q9QR71 LANA1			0.544	2
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.537	6
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.499	3
UniProt:Q77UV9 Q77UV9			0.499	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	3
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.462	3
IntAct:EBI-5276484 ACTB			0.462	2
IntAct:EBI-1265559 MYC			0.462	2

Cite Us!