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SUZ12 [nucleoplasm]
Stable Identifier
R-HSA-212217
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CHET9, JJAZ1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)
SUZ12 [nucleoplasm] (Homo sapiens)
Formation of PRC2-EZH2 complex (Homo sapiens)
SUZ12 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)
SUZ12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15022 SUZ12
Gene Names
SUZ12, CHET9, JJAZ1, KIAA0160
Chain
chain:1-739
Reference Genes
BioGPS Gene:23512 SUZ12
COSMIC (genes):SUZ12 SUZ12
CTD Gene:23512 SUZ12
dbSNP Gene:23512 SUZ12
ENSEMBL:ENSG00000178691 SUZ12
ENSEMBL_homo_sapiens_GENE:ENSG00000178691.11 SUZ12
HGNC:17101 SUZ12
KEGG Gene (Homo sapiens):23512 SUZ12
Monarch:23512 SUZ12
NCBI Gene:23512 SUZ12
OMIM:606245 SUZ12
UCSC:Q15022 SUZ12
Reference Transcript
RefSeq:NM_015355.3 SUZ12
Other Identifiers
11739485_a_at
11739486_at
11739487_s_at
16833037
212287_PM_at
212287_at
213971_PM_s_at
213971_s_at
23512
3716676
3716682
3716685
3716687
3717399
3717400
3717401
3717402
3717403
3717406
3717407
3717411
3717413
3717415
3717417
3717418
3717420
3717422
3717424
3717425
3717426
3717428
3717430
3717431
3717432
3717433
40957_at
8006325
A_14_P109382
A_23_P100883
A_32_P24223
D63881_at
GE81999
GO:0000122
GO:0000978
GO:0001222
GO:0001739
GO:0003677
GO:0003682
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005730
GO:0006325
GO:0006351
GO:0006355
GO:0008047
GO:0008283
GO:0008284
GO:0016586
GO:0016604
GO:0016740
GO:0030154
GO:0031490
GO:0032993
GO:0035064
GO:0035098
GO:0036211
GO:0042054
GO:0042393
GO:0043226
GO:0043565
GO:0045596
GO:0046872
GO:0048709
GO:0048856
GO:0060816
GO:0098772
GO:0106222
GO:0140096
GO:0140718
GO:1990841
GO:1990904
HMNXSV003041554
HMNXSV003057700
Hs.197803.0.A1_3p_at
Hs.197803.1.A1_3p_a_at
Hs.197803.1.A1_3p_x_at
ILMN_1797813
PH_hs_0023866
TC17000369.hg
Participates
as an input of
PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)
Formation of PRC2-EZH2 complex (Homo sapiens)
as an output of
E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K75-SUZ12 [nucleoplasm]
Inferred To
suz12b [nucleoplasm]
(Danio rerio)
Suz12 [nucleoplasm]
(Mus musculus)
Suz12 [nucleoplasm]
(Rattus norvegicus)
SWP82 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of SUZ12 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of SUZ12 [nucleoplasm]
(Gallus gallus)
suz12 [nucleoplasm]
(Xenopus tropicalis)
SUZ12 [nucleoplasm]
(Bos taurus)
SUZ12 [nucleoplasm]
(Canis familiaris)
SUZ12 [nucleoplasm]
(Sus scrofa)
Su(z)12 [nucleoplasm]
(Drosophila melanogaster)
rsc7 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_056170.2
OpenTargets
ENSG00000178691
GeneCards
Q15022
HPA
ENSG00000178691-SUZ12
Ensembl
ENSP00000316578
,
ENST00000322652
,
ENSG00000178691
PRO
Q15022
Pharos - Targets
Q15022
Orphanet
23226
PDB
7AT8
,
5WG6
,
5IJ8
,
6WKR
,
5WAI
,
6C23
,
4W2R
,
6B3W
,
6NQ3
,
5IJ7
,
7TD5
,
7KTP
,
7KSR
,
8FYH
,
5WAK
,
5LS6
,
7KSO
,
6C24
,
5HYN
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.957
31
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.909
12
UniProt:Q6ZN18 AEBP2
1
AEBP2 [nucleoplasm]
(R-HSA-5082342)
0.881
10
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.837
10
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.837
9
UniProt:Q92833 JARID2
1
JARID2 [nucleoplasm]
(R-HSA-2160949)
0.788
7
UniProt:Q92800 EZH1
0.725
6
UniProt:O43189 PHF1
1
PHF1 [nucleoplasm]
(R-HSA-5084105)
0.725
7
UniProt:Q9Y483 MTF2
1
MTF2 [nucleoplasm]
(R-HSA-5084119)
0.725
6
UniProt:Q96JN0 LCOR
0.706
6
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.643
6
UniProt:A6NHQ4 EPOP
0.643
5
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.597
13
UniProt:Q92833-1 JARID2
0.558
7
UniProt:Q1XH10 SKDA1
0.527
2
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.527
2
UniProt:P62249 RPS16
2
RPS16 [nucleoplasm]
(R-HSA-6791196)
RPS16 [cytosol]
(R-HSA-72337)
0.527
2
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.499
7
UniProt:Q15156 Q15156
0.499
6
UniProt:O75530-1 EED
0.488
2
UniProt:Q14774 HLX
0.471
2
UniProt:Q9UBC3 DNMT3B
2
SUMO1-K-DNMT3B [nucleoplasm]
(R-HSA-4655334)
DNMT3B [nucleoplasm]
(R-HSA-212316)
0.462
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.462
10
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.462
4
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