Reactome | EZH2 [nucleoplasm]

EZH2 [nucleoplasm]

Stable Identifier

R-HSA-212298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KMT6

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Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1

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External Reference Information

External Reference

UniProt:Q15910 EZH2

Gene Names

EZH2, KMT6

Chain

chain:1-746

Reference Genes

BioGPS Gene:2146 EZH2

COSMIC (genes):EZH2 EZH2

CTD Gene:2146 EZH2

dbSNP Gene:2146 EZH2

ENSEMBL:ENSG00000106462 EZH2

ENSEMBL_homo_sapiens_GENE:ENSG00000106462.12 EZH2

HGNC:3527 EZH2

KEGG Gene (Homo sapiens):2146 EZH2

Monarch:2146 EZH2

NCBI Gene:2146 EZH2

OMIM:601573 EZH2

UCSC:Q15910 EZH2

Reference Transcript

Other Identifiers

11717657_a_at

11748690_a_at

17064105

203358_PM_s_at

203358_s_at

2146

3078349

3078350

3078352

3078353

3078356

3078358

3078360

3078362

3078364

3078369

3078371

3078374

3078377

3078382

3078383

3078384

3078385

3078386

3078391

3078392

3078393

3078399

3078400

3078401

37305_at

3919611

3930675

8143663

A_23_P259641

A_33_P3252196

GE59277

GO:0000082

GO:0000122

GO:0000278

GO:0000781

GO:0000785

GO:0000976

GO:0000978

GO:0000979

GO:0001222

GO:0001932

GO:0002376

GO:0003012

GO:0003677

GO:0003682

GO:0003714

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005677

GO:0005694

GO:0005721

GO:0006306

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0008168

GO:0008284

GO:0009913

GO:0010468

GO:0010629

GO:0010718

GO:0014013

GO:0014834

GO:0014898

GO:0016279

GO:0016740

GO:0021695

GO:0021766

GO:0023052

GO:0030097

GO:0030154

GO:0030183

GO:0030216

GO:0031490

GO:0031507

GO:0031509

GO:0032200

GO:0032259

GO:0032355

GO:0034244

GO:0035098

GO:0035984

GO:0036211

GO:0036333

GO:0042054

GO:0042127

GO:0042752

GO:0043021

GO:0043226

GO:0043406

GO:0043547

GO:0043565

GO:0045120

GO:0045202

GO:0045605

GO:0045617

GO:0045814

GO:0045892

GO:0046976

GO:0048387

GO:0048511

GO:0048856

GO:0048863

GO:0050767

GO:0051154

GO:0051932

GO:0070301

GO:0070314

GO:0070734

GO:0070878

GO:0071168

GO:0071902

GO:0090183

GO:0097421

GO:0106222

GO:0140096

GO:0140110

GO:0140718

GO:0140938

GO:0140951

GO:1900006

GO:1900016

GO:1902808

GO:1904772

GO:1990841

GO:2000134

GO:2000737

HMNXSV003004831

ILMN_1652913

ILMN_1708105

ILMN_2364529

PH_hs_0025941

TC07001993.hg

U61145_at

g4758323_3p_a_at

Participates

as an output of

E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EZH2 [nucleoplasm] (Bos taurus)

EZH2 [nucleoplasm] (Canis familiaris)

EZH2 [nucleoplasm] (Gallus gallus)

EZH2 [nucleoplasm] (Sus scrofa)

ezh2 [nucleoplasm] (Danio rerio)

ezh2 [nucleoplasm] (Xenopus tropicalis)

Ezh2 [nucleoplasm] (Mus musculus)

Ezh2 [nucleoplasm] (Rattus norvegicus)

mes-2 [nucleoplasm] (Caenorhabditis elegans)

E(z) [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_694543.1, NP_001190176.1, NP_001190178.1, NP_004447.2, NP_001190177.1, XP_011514186.1

Guide to Pharmacology - Targets

2654

OpenTargets

ENSG00000106462

ZINC - Substances

EZH2_HUMAN

ZINC target

Q15910

PRO

Q15910

PDB

8FYH, 5H19, 5U5T, 5U62, 5H17, 5LS6, 5HYN, 4MI5, 6LO2, 7QK4, 5H15, 7AT8, 5WUK, 5H14, 6WKR, 7QJU, 6P5L, 6U4Y, 6C23, 5H25, 6C24, 4MI0, 5WG6, 5IJ7, 7QJG, 5H24, 5IJ8, 5GSA

ZINC - Investigational

EZH2_HUMAN

HPA

ENSG00000106462-EZH2

GeneCards

Q15910

Ensembl

ENST00000478654, ENSP00000419050, ENSP00000417062, ENST00000460911, ENST00000483967, ENST00000320356, ENST00000476773, ENSP00000320147, ENSP00000223193, ENSG00000106462, ENSP00000419856, ENSP00000419711, ENST00000350995

Pharos - Targets

Q15910

Orphanet

20793

ZINC - Predictions - Purchasable

EZH2_HUMAN

HMDB Protein

HMDBP09013

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.957	31
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.922	17
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.891	9
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.834	14
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.793	8
UniProt:Q96JN0 LCOR			0.788	6
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.788	7
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.725	6
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	7
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.725	5
UniProt:A6NHQ4 EPOP			0.725	6
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	7
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.693	8
UniProt:Q9Y6K1 DNMT3A	2	monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415) DNMT3A [nucleoplasm] (R-HSA-212287)	0.677	6
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.666	4
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.602	9
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.597	15
UniProt:P84243 H3-3A	18	MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) H3R17me2a [nucleoplasm] (R-HSA-9822613) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) H3F3A [extracellular region] (R-HSA-977567) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.597	7
UniProt:Q15156 Q15156			0.576	8
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.564	2
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.558	6
UniProt:Q92833-1 JARID2			0.558	7
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.527	7
UniProt:Q92800 EZH1			0.527	2
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.527	4
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.524	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.499	5
UniProt:Q9CWR8 Dnmt3l	1	Dnmt3l [nucleoplasm] (R-MMU-5334127)	0.499	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.462	2
UniProt:A4PIW0 A4PIW0			0.462	5
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.462	10

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