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MED12 [nucleoplasm]
Stable Identifier
R-HSA-212343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:P49336
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
MED12 [nucleoplasm] (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
MED12 [nucleoplasm] (Homo sapiens)
Formation of TRAP coactivator complex (Homo sapiens)
MED12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q93074 MED12
Gene Names
MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Chain
chain:1-2177
Reference Genes
BioGPS Gene:9968 MED12
COSMIC (genes):MED12 MED12
CTD Gene:9968 MED12
dbSNP Gene:9968 MED12
ENSEMBL:ENSG00000184634 MED12
ENSEMBL_homo_sapiens_GENE:ENSG00000184634.17 MED12
HGNC:11957 MED12
KEGG Gene (Homo sapiens):9968 MED12
Monarch:9968 MED12
NCBI Gene:9968 MED12
OMIM:300188 MED12
UCSC:Q93074 MED12
Reference Transcript
RefSeq:NM_005120.2 MED12
Other Identifiers
11723361_a_at
17104587
203506_PM_s_at
203506_s_at
211342_PM_x_at
211342_x_at
216071_PM_x_at
216071_x_at
3980759
3980760
3980761
3980763
3980764
3980765
3980766
3980767
3980768
3980769
3980770
3980771
3980772
3980773
3980774
3980775
3980776
3980778
3980779
3980780
3980781
3980782
3980783
3980784
3980785
3980786
3980788
3980789
3980790
3980791
3980792
3980794
3980795
3980796
3980798
3980799
3980800
3980801
3980803
3980804
3980805
3980806
3980809
3980810
3980812
3980814
3980816
3980818
3980819
3980820
3980825
3980826
3980827
3980828
3980829
3980830
3980831
3980832
3980834
3980836
3980837
3980838
3980839
40998_at
8168215
9968
D83783_at
GE729352
GE81473
GO:0000151
GO:0000978
GO:0001756
GO:0001843
GO:0003677
GO:0003682
GO:0003712
GO:0003713
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0006357
GO:0007492
GO:0007507
GO:0008013
GO:0014003
GO:0014044
GO:0016020
GO:0016567
GO:0016592
GO:0016740
GO:0021510
GO:0021915
GO:0023052
GO:0030154
GO:0030374
GO:0035019
GO:0036211
GO:0036342
GO:0042809
GO:0043226
GO:0045893
GO:0045944
GO:0046966
GO:0048568
GO:0048702
GO:0048856
GO:0060071
GO:0060261
GO:0061630
GO:0090245
GO:0140096
GO:0140110
GO:1990403
GO:1990508
HMNXSV003048336
PH_hs_0024789
TC0X000382.hg
TC0X001752.hg
TC0X001753.hg
g4827041_3p_a_at
Participates
as a component of
TRAP coactivator complex [nucleoplasm] (Homo sapiens)
DRIP coactivator complex [nucleoplasm] (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
as an input of
Formation of TRAP coactivator complex (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
Inferred To
med12 [nucleoplasm]
(Danio rerio)
Med12 [nucleoplasm]
(Mus musculus)
Med12 [nucleoplasm]
(Rattus norvegicus)
kto [nucleoplasm]
(Drosophila melanogaster)
MED12 [nucleoplasm]
(Bos taurus)
MED12 [nucleoplasm]
(Gallus gallus)
MED12 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005111.2
OpenTargets
ENSG00000184634
HPA
ENSG00000184634-MED12
GeneCards
Q93074
Ensembl
ENST00000374080
,
ENSG00000184634
,
ENSP00000363193
,
ENSP00000363215
,
ENST00000692304
,
ENSP00000508427
,
ENST00000374102
PRO
Q93074
Pharos - Targets
Q93074
Orphanet
16796
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.899
17
UniProt:Q9BWU1 CDK19
1
CDK19 [nucleoplasm]
(R-HSA-556782)
0.848
6
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.727
8
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.725
5
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.677
5
UniProt:Q9NWA0 MED9
1
MED9 [nucleoplasm]
(R-HSA-556804)
0.643
3
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.643
3
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.643
3
UniProt:Q92830 KAT2A
1
KAT2A [nucleoplasm]
(R-HSA-3006516)
0.527
2
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.527
2
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.527
2
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.527
2
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.527
3
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.527
2
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
5
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.527
2
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.524
3
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.483
2
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.471
2
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