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CTBP1 [nucleoplasm]
Stable Identifier
R-HSA-212372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CtBP
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by TCF7L2 mutants (Homo sapiens)
TFC7L2 mutants don't bind CTBP (Homo sapiens)
CTBPs [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)
CTBPs [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
TCF7L2/TCF7L1:CTBPs [nucleoplasm] (Homo sapiens)
CTBPs [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
CTBPs [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
TCF7L2/TCF7L1:CTBPs [nucleoplasm] (Homo sapiens)
CTBPs [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13363 CTBP1
Gene Names
CTBP1, CTBP
Chain
chain:1-440
Reference Genes
BioGPS Gene:1487 CTBP1
COSMIC (genes):CTBP1 CTBP1
CTD Gene:1487 CTBP1
dbSNP Gene:1487 CTBP1
ENSEMBL:ENSG00000159692 CTBP1
HGNC:2494 CTBP1
KEGG Gene (Homo sapiens):1487 CTBP1
Monarch:1487 CTBP1
NCBI Gene:1487 CTBP1
OMIM:602618 CTBP1
UCSC:Q13363 CTBP1
Reference Transcript
RefSeq:NM_001328.2 CTBP1
RefSeq:NM_001012614.1 CTBP1
RefSeq:XM_017007765.1 CTBP1
RefSeq:XM_017007764.1 CTBP1
RefSeq:XM_017007766.1 CTBP1
RefSeq:XM_017007767.1 CTBP1
Other Identifiers
11719960_a_at
11719961_s_at
11738637_a_at
11745679_a_at
1487
203392_s_at
212863_x_at
213980_s_at
2757035
2757037
2757038
2757039
2757040
2757041
2757042
2757043
2757046
2757048
2757051
2757058
2757059
2757071
2757072
2757073
2757080
2757103
2757104
2757112
2757113
41308_at
41309_g_at
43382_s_at
55310_at
8098880
A_23_P41286
A_23_P41292
A_24_P208992
A_33_P3357979
GE61587
GO:0000122
GO:0001226
GO:0003674
GO:0003682
GO:0003714
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006342
GO:0006464
GO:0006468
GO:0007049
GO:0008022
GO:0008134
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0016032
GO:0016491
GO:0016616
GO:0017053
GO:0019079
GO:0019904
GO:0030154
GO:0031065
GO:0032991
GO:0034641
GO:0035067
GO:0042802
GO:0043226
GO:0044403
GO:0045892
GO:0050872
GO:0051276
GO:0051287
GO:0051726
GO:0055114
GO:0070491
GO:0090241
Hs.239737.2.A1_3p_a_at
Hs.239737.2.A1_3p_x_at
ILMN_1719158
ILMN_1782327
ILMN_2278235
ILMN_2379734
TC04000963.hg
U37408_at
g4557496_3p_a_at
Participant Of
input
APC promotes disassembly of beta-catenin transactivation complex
PRC1 SUMOylates CTBP1 with SUMO1
PRC1 SUMOylates CTBP1 with SUMO2,3
hasMember
CTBPs [nucleoplasm]
hasComponent
APC:CTBP:CTNNB1:BTRC [nucleoplasm]
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
Other forms of this molecule
SUMO1-K428-CTBP1 [nucleoplasm]
SUMO2,3-K428-CTBP1 [nucleoplasm]
Inferred To
CtBP [nucleoplasm] (Drosophila melanogaster)
Ctbp1 [nucleoplasm] (Mus musculus)
Ctbp1 [nucleoplasm] (Rattus norvegicus)
ctbp-1 [nucleoplasm] (Caenorhabditis elegans)
CTBP1 [nucleoplasm] (Bos taurus)
CTBP1 [nucleoplasm] (Canis familiaris)
CTBP1 [nucleoplasm] (Danio rerio)
CTBP1 [nucleoplasm] (Gallus gallus)
CTBP1 [nucleoplasm] (Sus scrofa)
ctbp1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
XP_016863256.1
,
XP_016863255.1
,
XP_016863254.1
,
NP_001319.1
,
NP_001012632.1
,
XP_016863253.1
OpenTargets
ENSG00000159692
HPA
ENSG00000159692-CTBP1
GeneCards
Q13363
Ensembl
ENSG00000159692
,
ENSP00000290921
,
ENSP00000372411
,
ENST00000382952
,
ENST00000290921
PRO
Q13363
HMDB Protein
HMDBP02216
PDB
6CDF
,
4U6Q
,
6CDR
,
4LCE
,
1MX3
,
4U6S
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99708 RBBP8
4
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
Ac-K432,K526,K604-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
0.691
4
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
SUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
SUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
0.668
4
UniProt:P56545 CTBP2
1
CTBP2 [nucleoplasm]
(R-HSA-5333990)
0.667
3
UniProt:Q8N3X6 LCORL
0.659
3
UniProt:Q8N895 ZN366
0.633
5
UniProt:O00257 CBX4
2
CBX4 [nucleoplasm]
(R-HSA-389118)
SUMO1-K494-CBX4 [nucleoplasm]
(R-HSA-4551626)
0.602
4
UniProt:P03255 E1A
0.593
3
UniProt:P48552 NRIP1
2
NRIP1 [nucleoplasm]
(R-HSA-4086031)
SUMO1-K756,K1154-NRIP1 [nucleoplasm]
(R-HSA-4086057)
0.592
2
UniProt:Q14526 HIC1
2
HIC1 [nucleoplasm]
(R-HSA-4090364)
SUMO1-K333-HIC1 [nucleoplasm]
(R-HSA-4090368)
0.573
2
UniProt:P37275 ZEB1
1
ZEB1 [nucleoplasm]
(R-HSA-6789836)
0.564
2
UniProt:Q96JN0-2 LCOR
0.547
2
UniProt:Q69140 EBNA6
0.544
2
UniProt:P25054 APC
86
APC C1410* [cytosol]
(R-HSA-9666925)
APC R213* [cytosol]
(R-HSA-9666924)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
APC G1312* [cytosol]
(R-HSA-9666931)
APC R283* [cytosol]
(R-HSA-9666988)
APC Q1367* [cytosol]
(R-HSA-9666989)
APC E1353* [cytosol]
(R-HSA-9666990)
APC R332* [cytosol]
(R-HSA-9666991)
APC K993* [cytosol]
(R-HSA-9666984)
APC R876* [cytosol]
(R-HSA-9666985)
APC R302* [cytosol]
(R-HSA-9666986)
APC E1309* [cytosol]
(R-HSA-9666987)
APC Y935* [cytosol]
(R-HSA-9666980)
APC E1286* [cytosol]
(R-HSA-9666981)
APC Q1378* [cytosol]
(R-HSA-9666982)
APC R554* [cytosol]
(R-HSA-9666983)
APC S1356* [cytosol]
(R-HSA-9666976)
APC R232* [cytosol]
(R-HSA-9666977)
APC E1379* [cytosol]
(R-HSA-9666978)
APC E984* [cytosol]
(R-HSA-9666979)
APC R1114* [cytosol]
(R-HSA-9666996)
APC S1282* [cytosol]
(R-HSA-9666997)
APC Q1328* [cytosol]
(R-HSA-9666998)
APC E1295* [cytosol]
(R-HSA-9666992)
APC E1151* [cytosol]
(R-HSA-9666993)
APC E1322* [cytosol]
(R-HSA-9666994)
APC E1345* [cytosol]
(R-HSA-9666995)
APC K1308* [cytosol]
(R-HSA-9666956)
APC S1344* [cytosol]
(R-HSA-9666957)
APC E1577* [cytosol]
(R-HSA-9666958)
APC Q1127* [cytosol]
(R-HSA-9666959)
APC E1464* [cytosol]
(R-HSA-9666952)
APC E1317* [cytosol]
(R-HSA-9666953)
APC G1309Dfs*4 [cytosol]
(R-HSA-4791251)
APC W1049* [cytosol]
(R-HSA-9666954)
APC Q1429* [cytosol]
(R-HSA-9666955)
APC L1564* [cytosol]
(R-HSA-9666948)
APC Q1294* [cytosol]
(R-HSA-9666949)
APC K1363* [cytosol]
(R-HSA-9666950)
APC E1408* [cytosol]
(R-HSA-9666951)
APC E1284* [cytosol]
(R-HSA-9666944)
APC E1374* [cytosol]
(R-HSA-9666945)
APC Q767* [cytosol]
(R-HSA-9666946)
APC E941* [cytosol]
(R-HSA-9666947)
APC Q1303* [cytosol]
(R-HSA-9666972)
APC S943* [cytosol]
(R-HSA-9666973)
APC E1306* [cytosol]
(R-HSA-9666975)
APC S895* [cytosol]
(R-HSA-9666969)
APC S1315* [cytosol]
(R-HSA-9666970)
APC G1412* [cytosol]
(R-HSA-9666971)
APC Y1376* [cytosol]
(R-HSA-9666964)
APC Q886* [cytosol]
(R-HSA-9666965)
APC S1392* [cytosol]
(R-HSA-9666966)
APC S1539* [cytosol]
(R-HSA-9666967)
APC E1451* [cytosol]
(R-HSA-9666960)
APC E1397* [cytosol]
(R-HSA-9666961)
APC Q1406* [cytosol]
(R-HSA-9666962)
APC E1544* [cytosol]
(R-HSA-9666963)
APC F1197* [cytosol]
(R-HSA-5246655)
APC Q1338* [cytosol]
(R-HSA-5246654)
APC S811* [cytosol]
(R-HSA-5246652)
APC I1417 fs*2 [cytosol]
(R-HSA-5246651)
APC E1554* [cytosol]
(R-HSA-5246648)
APC(1-777) [cytosol]
(R-HSA-2976014)
APC(778-2843) [cytosol]
(R-HSA-2976013)
APC [cytosol]
(R-HSA-2976015)
p-ub-APC [cytosol]
(R-HSA-3009421)
K63polyUb-APC [cytosol]
(R-HSA-5246690)
APC [nucleoplasm]
(R-HSA-3361755)
0.527
2
UniProt:Q96JN0 LCOR
0.527
2
UniProt:O75362 ZNF217
1
ZNF217 [nucleoplasm]
(R-HSA-9011738)
0.527
2
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.524
4
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.508
2
UniProt:Q96EK4 THA11
0.508
2
UniProt:Q9BXL5 HEMGN
0.508
2
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
UniProt:A2APF7 A2APF7
0.499
2
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