Reactome | CTBP1 [nucleoplasm]

CTBP1 [nucleoplasm]

Stable Identifier

R-HSA-212372

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CtBP

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by WNT in cancer (Homo sapiens)
    - Signaling by TCF7L2 mutants (Homo sapiens)
      - TFC7L2 mutants don't bind CTBP (Homo sapiens)
        
        CTBPs [nucleoplasm] (Homo sapiens)
        
        CTBP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13363 CTBP1

Gene Names

CTBP1, CTBP

Chain

chain:1-440

Reference Genes

BioGPS Gene:1487 CTBP1

COSMIC (genes):CTBP1 CTBP1

CTD Gene:1487 CTBP1

dbSNP Gene:1487 CTBP1

ENSEMBL:ENSG00000159692 CTBP1

ENSEMBL:ENSG00000159692.17 CTBP1

HGNC:2494 CTBP1

KEGG Gene (Homo sapiens):1487 CTBP1

Monarch:1487 CTBP1

NCBI Gene:1487 CTBP1

OMIM:602618 CTBP1

UCSC:Q13363 CTBP1

Reference Transcript

Other Identifiers

11719960_a_at

11719961_s_at

11738637_a_at

11745679_a_at

1487

203392_PM_s_at

203392_s_at

212863_PM_x_at

212863_x_at

213980_PM_s_at

213980_s_at

2757035

2757037

2757038

2757039

2757040

2757041

2757042

2757043

2757046

2757048

2757051

2757058

2757059

2757071

2757072

2757073

2757080

2757103

2757104

2757106

2757112

2757113

41308_at

41309_g_at

43382_s_at

55310_at

8098880

A_23_P41286

A_23_P41292

A_24_P208992

A_33_P3357979

GE61587

GO:0000122

GO:0001221

GO:0001222

GO:0003682

GO:0003713

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0008285

GO:0016192

GO:0016491

GO:0016616

GO:0017053

GO:0019079

GO:0019904

GO:0030154

GO:0031065

GO:0031507

GO:0035067

GO:0036211

GO:0042802

GO:0043226

GO:0045892

GO:0045893

GO:0048488

GO:0050872

GO:0051287

GO:0051726

GO:0061629

GO:0090241

GO:0097091

GO:0098831

GO:0098978

GO:0098982

GO:0140110

GO:0140297

HMNXSV003052557

Hs.239737.2.A1_3p_a_at

Hs.239737.2.A1_3p_x_at

ILMN_1719158

ILMN_2278235

ILMN_2379734

TC04000963.hg

U37408_at

g4557496_3p_a_at

Participates

as an input of

as a member of

CTBPs [nucleoplasm] (Homo sapiens)

as a component of

Other forms of this molecule

monoSUMO1-K428-CTBP1 [nucleoplasm]

polySUMO2,3-K428-CTBP1 [nucleoplasm]

Inferred To

fa96d06 [nucleoplasm] (Danio rerio)

CTBP1 [nucleoplasm] (Bos taurus)

CTBP1 [nucleoplasm] (Caenorhabditis elegans)

CTBP1 [nucleoplasm] (Canis familiaris)

CTBP1 [nucleoplasm] (Drosophila melanogaster)

CTBP1 [nucleoplasm] (Gallus gallus)

CTBP1 [nucleoplasm] (Mus musculus)

CTBP1 [nucleoplasm] (Rattus norvegicus)

CTBP1 [nucleoplasm] (Sus scrofa)

ctbp1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_016863255.1, XP_016863253.1, NP_001012632.1, XP_016863256.1, XP_016863254.1, NP_001319.1

OpenTargets

ENSG00000159692

GeneCards

Q13363

HPA

ENSG00000159692-CTBP1

Ensembl

ENST00000290921, ENST00000382952, ENSP00000515211, ENST00000703163, ENSP00000515195, ENSP00000372411, ENST00000703138, ENSG00000159692, ENSP00000290921

PRO

Q13363

Pharos - Targets

Q13363

Orphanet

29802

HMDB Protein

HMDBP02216

PDB

7KWM, 6V8A, 6CDR, 4U6Q, 4U6S, 4LCE, 1MX3, 6V89, 6CDF

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.897	14
UniProt:Q92618 ZN516			0.805	14
UniProt:Q8N3X6 LCORL			0.788	6
UniProt:Q96JN0 LCOR			0.788	8
UniProt:P37275 ZEB1	1	ZEB1 [nucleoplasm] (R-HSA-6789836)	0.763	10
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.748	8
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.745	9
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.745	5
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.691	4
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.683	3
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.671	7
UniProt:Q99592 ZBT18			0.67	5
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.643	6
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.643	9
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	7
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.643	5
UniProt:Q8N895 ZN366			0.633	5
UniProt:Q96EK4 THA11			0.632	3
UniProt:O95785 WIZ			0.615	6
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.602	4
UniProt:Q9Y5P3 RAI2			0.594	3
UniProt:P03255 E1A			0.593	3
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.573	2
UniProt:O15409 FOXP2			0.553	2
UniProt:A7XYQ1 SOBP			0.547	2
UniProt:Q96JN0-2 LCOR			0.547	2
UniProt:Q69140 EBNA6			0.544	2
UniProt:Q96MY1 NOL4L			0.527	5
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.527	8
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	3
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.527	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.527	2
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.524	4
UniProt:P57682 KLF3			0.519	2
UniProt:Q9Y4X4 KLF12			0.519	2
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.508	2
UniProt:Q9BXL5 HEMGN			0.508	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:A2APF7 A2APF7			0.499	2
UniProt:Q9HAZ2 PRDM16	1	PRDM16 [cytosol] (R-HSA-5634812)	0.483	2
UniProt:Q03112 MECOM	2	MECOM [cytosol] (R-HSA-5634790) MECOM [nucleoplasm] (R-HSA-8943897)	0.483	2
UniProt:Q8NDX5 PHC3	1	PHC3 [nucleoplasm] (R-HSA-389116)	0.483	2
UniProt:Q9UHF7 TRPS1			0.483	2
UniProt:O94818 NOL4			0.483	2
UniProt:Q96AV8 E2F7	1	E2F7 [nucleoplasm] (R-HSA-6798305)	0.483	2
UniProt:Q5H9F3 BCORL			0.483	2
UniProt:Q13029 PRDM2			0.483	2

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