Reactome | MED25 [nucleoplasm]

MED25 [nucleoplasm]

Stable Identifier

R-HSA-212414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q53G59 KLHL12

Expand all

External Reference Information

External Reference

UniProt:Q71SY5 MED25

Gene Names

MED25, ACID1, ARC92, PTOV2, TCBAP0758

Chain

chain:1-747

Reference Genes

BioGPS Gene:81857 MED25

COSMIC (genes):MED25 MED25

CTD Gene:81857 MED25

dbSNP Gene:81857 MED25

ENSEMBL:ENSG00000104973 MED25

HGNC:28845 MED25

KEGG Gene (Homo sapiens):81857 MED25

Monarch:81857 MED25

NCBI Gene:81857 MED25

OMIM:610197 MED25

UCSC:Q71SY5 MED25

Reference Transcript

RefSeq:NM_030973.3 MED25

Other Identifiers

0003520348

11731378_a_at

11731379_x_at

11745161_x_at

11749499_x_at

11753112_x_at

11753437_a_at

11753438_x_at

11753525_a_at

11753526_x_at

11753728_x_at

1553993_s_at

16864331

3838948

3838949

3838950

3838952

3838954

3838955

3838959

3838962

3838963

3838966

3838967

3838968

3838969

3838970

3838971

3838972

3838974

3838975

3838976

3838978

3838981

3838982

3838983

3838984

3838985

3838986

3838987

3838988

3838989

3838990

3838995

3838996

3839030

8030498

81857

A_23_P153510

A_33_P3322553

A_33_P3378212

GE83211

GO:0000122

GO:0001223

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0006367

GO:0007049

GO:0008134

GO:0008150

GO:0008283

GO:0009058

GO:0016592

GO:0022607

GO:0032991

GO:0034641

GO:0035563

GO:0042974

GO:0043226

GO:0045944

GO:0046965

GO:0048147

GO:0065003

GO:0071158

GO:2001178

Hs2.293678.2.S1_3p_s_at

ILMN_1811823

PH_hs_0034667

TC19000748.hg

TC19002200.hg

Participant Of

hasComponent

input

Formation of ARC coactivator complex

Inferred To

MED25 [nucleoplasm] (Canis familiaris)

med25 [nucleoplasm] (Danio rerio)

med25 [nucleoplasm] (Xenopus tropicalis)

Med25 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_112235.2

OpenTargets

ENSG00000104973

HPA

ENSG00000104973-MED25

GeneCards

Q71SY5

Ensembl

ENST00000312865, ENST00000538643, ENSP00000437496, ENSG00000104973, ENSP00000326767

PRO

Q71SY5

Orphanet

17685

PDB

2XNF, 2L6U, 2L23, 2KY6

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:G8HBG2 G8HBG2			0.737	5
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.69	6
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.648	3
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.643	3
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.625	4
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.564	2
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.564	2
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.564	2
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.564	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9NZQ3-3 NCKIPSD			0.556	3
UniProt:A1E959 ODAM	1	ODAM [extracellular region] (R-HSA-977149)	0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:O00167-2 EYA2			0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q92753-1 Q927531			0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1-RAF1 fusion [cytosol] (R-HSA-6802312) p-ESRP1-RAF1 fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P51692 STAT5B	5	p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.556	3
UniProt:Q92734 TFG	1	TFG [cytosol] (R-HSA-5688159)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
IntAct:EBI-22311199 CCSB ORF ID			0.556	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	2
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4
UniProt:P10276 RARA	3	SUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) RARA [nucleoplasm] (R-HSA-446164)	0.508	10

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