Reactome | MED25 [nucleoplasm]

MED25 [nucleoplasm]

Stable Identifier

R-HSA-212414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q6NXG1 ESRP1

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External Reference Information

External Reference

UniProt:Q71SY5 MED25

Gene Names

MED25, ACID1, ARC92, PTOV2, TCBAP0758

Chain

chain:1-747

Reference Genes

BioGPS Gene:81857 MED25

COSMIC (genes):MED25 MED25

CTD Gene:81857 MED25

dbSNP Gene:81857 MED25

ENSEMBL:ENSG00000104973 MED25

HGNC:28845 MED25

KEGG:hsa:81857 MED25

Monarch:81857 MED25

NCBI Gene:81857 MED25

OMIM:610197 MED25

UCSC:Q71SY5 MED25

Reference Transcript

RefSeq:NM_030973.3 MED25

Other Identifiers

11731378_a_at

11731379_x_at

11745161_x_at

11749499_x_at

11753112_x_at

11753437_a_at

11753438_x_at

11753525_a_at

11753526_x_at

11753728_x_at

11762983_a_at

11763477_a_at

1553993_PM_s_at

1553993_s_at

16864331

208110_PM_x_at

208110_x_at

215897_PM_at

215897_at

32130_at

3838948

3838949

3838950

3838952

3838953

3838954

3838955

3838959

3838962

3838963

3838966

3838967

3838968

3838969

3838970

3838971

3838972

3838974

3838975

3838976

3838978

3838979

3838980

3838981

3838982

3838983

3838984

3838985

3838986

3838987

3838988

3838989

3838990

3838991

3838992

3838993

3838994

3838995

3838996

3838997

3838998

3838999

3839000

3839002

3839005

3839030

8030498

81857

92049_at

A_23_P153510

A_33_P3322553

A_33_P3378212

GE83211

GE87642

GO:0000122

GO:0001223

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0006355

GO:0016592

GO:0032968

GO:0035563

GO:0042974

GO:0043226

GO:0045944

GO:0046965

GO:0048147

GO:0051123

GO:0060261

GO:0065003

GO:0070847

GO:2001178

HMNXSV003007058

HMNXSV003038253

Hs.293678.1.S1_3p_at

Hs2.293678.2.S1_3p_s_at

ILMN_1811823

PH_hs_0034667

TC19000748.hg

TC19002200.hg

Participates

as a component of

as an input of

Formation of ARC coactivator complex (Homo sapiens)

Inferred To

MED25 [nucleoplasm] (Bos taurus)

MED25 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_112235.2

OpenTargets

ENSG00000104973

ENSEMBL

ENSP00000437496, ENSP00000326767, ENST00000312865, ENST00000538643

HPA

ENSG00000104973-MED25

PRO

Q71SY5

Pharos - Targets

Q71SY5

GlyGen

Q71SY5

Orphanet

MED25

PDB

8GXS, 8GXQ, 2XNF, 7EMF, 2L23, 2L6U, 7LBM, 2KY6

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.793	7
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.788	6
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.763	5
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.745	7
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.744	5
UniProt:G8HBG2 G8HBG2			0.737	5
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.669	4
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.669	3
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.643	3
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	5
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.643	4
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.643	5
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.625	4
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P51692 STAT5B	4	p-STAT5B [cytosol] (R-HSA-8983127) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.556	3
UniProt:Q92734 TFG	7	TFG [cytosol] (R-HSA-5688159) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q92753-1 Q927531			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:O00167-2 EYA2			0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:A1E959 ODAM	1	ODAM [extracellular region] (R-HSA-977149)	0.556	3
UniProt:Q9NZQ3-3 NCKIPSD			0.556	3
UniProt:Q70EL1-9 USP54			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.527	3
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	4
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.527	3
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.508	10

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