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What is Reactome ?
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Go!
CCNC [nucleoplasm]
Stable Identifier
R-HSA-212418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CycC
Locations in the PathwayBrowser for interactor UniProt:P61086 UBE2K
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
CCNC [nucleoplasm] (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
CCNC [nucleoplasm] (Homo sapiens)
Formation of TRAP coactivator complex (Homo sapiens)
CCNC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24863 CCNC
Gene Names
CCNC
Chain
chain:1-283
Reference Genes
BioGPS Gene:892 CCNC
COSMIC (genes):CCNC CCNC
CTD Gene:892 CCNC
dbSNP Gene:892 CCNC
ENSEMBL:ENSG00000112237 CCNC
ENSEMBL_homo_sapiens_GENE:ENSG00000112237.13 CCNC
HGNC:1581 CCNC
KEGG Gene (Homo sapiens):892 CCNC
Monarch:892 CCNC
NCBI Gene:892 CCNC
OMIM:123838 CCNC
UCSC:P24863 CCNC
Reference Transcript
RefSeq:NM_005190.3 CCNC
RefSeq:NM_001013399.1 CCNC
Other Identifiers
11726983_s_at
11726984_a_at
11726985_x_at
1923_at
201955_PM_at
201955_at
2966373
2966374
2966375
2966376
2966377
2966378
2966379
2966380
2966381
2966386
2966389
2966394
2966398
2966401
2966403
2966409
2966411
2966412
2966415
2966420
2966421
2966422
2966423
39251_at
74582_s_at
8128429
88037_at
892
A_23_P145397
GO:0000307
GO:0005515
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0006357
GO:0016538
GO:0016592
GO:0023052
GO:0042802
GO:0043226
GO:0045023
GO:0045746
GO:0045944
GO:0098772
GO:1990508
HMNXSV003019843
Hs.118442.0.A2_3p_at
ILMN_1676423
ILMN_1798705
ILMN_2409395
M74091_at
Participates
as a component of
TRAP coactivator complex [nucleoplasm] (Homo sapiens)
DRIP coactivator complex [nucleoplasm] (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
as an input of
Formation of TRAP coactivator complex (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
Inferred To
ccnc [nucleoplasm]
(Danio rerio)
ccnc [nucleoplasm]
(Xenopus tropicalis)
Ccnc [nucleoplasm]
(Mus musculus)
Ccnc [nucleoplasm]
(Rattus norvegicus)
cycC [nucleoplasm]
(Dictyostelium discoideum)
cic-1 [nucleoplasm]
(Caenorhabditis elegans)
SSN8 [nucleoplasm]
(Saccharomyces cerevisiae)
CycC [nucleoplasm]
(Drosophila melanogaster)
srb11 [nucleoplasm]
(Schizosaccharomyces pombe)
CCNC [nucleoplasm]
(Bos taurus)
CCNC [nucleoplasm]
(Canis familiaris)
CCNC [nucleoplasm]
(Gallus gallus)
CCNC [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005181.2
,
NP_001013417.1
OpenTargets
ENSG00000112237
HPA
ENSG00000112237-CCNC
GeneCards
P24863
Ensembl
ENSG00000112237
,
ENSP00000430014
,
ENST00000523985
,
ENST00000520429
,
ENSP00000430119
,
ENST00000523799
,
ENSP00000428982
PRO
P24863
Pharos - Targets
P24863
PDB
4F6S
,
4F7S
,
5ICP
,
5HNB
,
5HBE
,
6Y0A
,
4F6U
,
5HBH
,
6QTJ
,
4F6W
,
5CEI
,
4F70
,
5HBJ
,
5I5Z
,
6QTG
,
5FGK
,
5HVY
,
4CRL
,
6R3S
,
4G6L
,
6T41
,
5IDN
,
5XQX
,
5BNJ
,
3RGF
,
6TPA
,
4F7L
,
4F7J
,
5XS2
,
5IDP
,
4F7N
Interactors (110)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.978
40
UniProt:Q9BWU1 CDK19
1
CDK19 [nucleoplasm]
(R-HSA-556782)
0.848
8
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.782
7
UniProt:Q00526 CDK3
0.75
7
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.748
7
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.725
5
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.669
4
UniProt:Q9HCM9 TRIM39
1
TRIM39 [cytosol]
(R-HSA-5688971)
0.666
4
UniProt:O43186 CRX
0.666
4
UniProt:P17022 ZNF18
1
ZNF18 [nucleoplasm]
(R-HSA-975005)
0.666
4
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.666
4
UniProt:Q9HAN9 NMNAT1
1
NMNAT1 [nucleoplasm]
(R-HSA-200484)
0.666
4
UniProt:Q96PV4 PNMA5
0.666
4
UniProt:Q96AQ6 PBIP1
0.666
5
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.643
4
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.643
5
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.643
5
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.643
4
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.643
5
UniProt:Q9UHV7 MED13
1
MED13 [nucleoplasm]
(R-HSA-212391)
0.641
5
UniProt:O75448 MED24
1
MED24 [nucleoplasm]
(R-HSA-212331)
0.564
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:Q3KQV3 ZNF792
1
ZNF792 [nucleoplasm]
(R-HSA-3110242)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:Q96JP2 MY15B
0.556
3
UniProt:Q92529 SHC3
2
SHC3 [cytosol]
(R-HSA-3006448)
p-Y-SHC3 [cytosol]
(R-HSA-3009043)
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:P17568 NDUFB7
1
NDUFB7 [mitochondrial inner membrane]
(R-HSA-59940)
0.556
3
UniProt:Q8TF47 ZFP90
1
ZFP90 [nucleoplasm]
(R-HSA-974988)
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q9BUY5 ZNF426
1
ZNF426 [nucleoplasm]
(R-HSA-1247530)
0.556
3
UniProt:Q8TD55-2 PLEKHO2
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q8WWB3 DYDC1
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:O15409 FOXP2
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q9BX70 BTBD2
0.556
3
UniProt:I6L9F6 I6L9F6
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9UHX1 PUF60
1
PUF60 [nucleoplasm]
(R-HSA-8865910)
0.556
3
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.556
3
UniProt:Q49A26 GLYR1
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q9Y371 SHLB1
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.556
3
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:O95983-2 MBD3
0.556
3
UniProt:P0C7X2 ZNF688
1
ZNF688 [nucleoplasm]
(R-HSA-2248884)
0.556
3
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q9Y247 FA50B
0.556
3
UniProt:P08779 KRT16
1
KRT16 [cytosol]
(R-HSA-201581)
0.556
3
UniProt:Q86YD7 F90A1
0.556
3
UniProt:Q6PJQ5 FOXR2
0.556
3
UniProt:P40337-2 VHL
0.556
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:O60664 PLIN3
7
p-PLIN3 [lysosomal lumen]
(R-HSA-9639396)
p-PLIN3 [cytosol]
(R-HSA-9613664)
p-PLIN3 [lipid droplet]
(R-HSA-9613539)
PLIN3 [lipid droplet]
(R-HSA-9613337)
p-PLIN3 [late endosome lumen]
(R-HSA-9639393)
PLIN3 [cytosol]
(R-HSA-6814628)
PLIN3 [transport vesicle]
(R-HSA-6813900)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:Q96F24 NRBF2
0.556
3
UniProt:Q9BVN2 RUSC1
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
5
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:Q6ZRS2-3 SRCAP
0.556
3
UniProt:Q8N443 RIBC1
0.556
5
UniProt:A1A4E9 A1A4E9
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:P15927 RPA2
2
RPA2 [nucleoplasm]
(R-HSA-68457)
p-S33-RPA2 [nucleoplasm]
(R-HSA-5685148)
0.556
3
UniProt:Q96N21 AP4AT
0.556
3
UniProt:Q6QNY1 BL1S2
0.556
3
UniProt:Q96IZ5 RBM41
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:O75528 TADA3
1
TADA3 [nucleoplasm]
(R-HSA-3322966)
0.556
3
UniProt:Q9NP79 VTA1
1
VTA1 [cytosol]
(R-HSA-917735)
0.556
3
UniProt:Q96M91 CFA53
0.556
3
UniProt:Q9UJW9 SRTD3
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P42772 CDKN2B
1
CDKN2B [cytosol]
(R-HSA-182586)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.556
3
UniProt:Q71F56 MED13L
1
MED13L [nucleoplasm]
(R-HSA-556797)
0.527
3
UniProt:Q9P086 MED11
1
MED11 [nucleoplasm]
(R-HSA-556808)
0.527
3
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.527
3
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.527
3
UniProt:Q9NWA0 MED9
1
MED9 [nucleoplasm]
(R-HSA-556804)
0.527
3
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.527
3
UniProt:Q9H204 MED28
1
MED28 [nucleoplasm]
(R-HSA-6804546)
0.527
3
UniProt:Q15528 MED22
1
MED22 [nucleoplasm]
(R-HSA-556779)
0.527
3
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.527
2
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.527
4
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.527
3
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.527
3
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.527
3
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.524
4
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.483
3
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