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CDK8 [nucleoplasm]
Stable Identifier
R-HSA-212440
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:Q71SY5
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
CDK8 [nucleoplasm] (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
CDK8 [nucleoplasm] (Homo sapiens)
Formation of TRAP coactivator complex (Homo sapiens)
CDK8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49336 CDK8
Gene Names
CDK8
Chain
chain:1-464
Reference Genes
BioGPS Gene:1024 CDK8
COSMIC (genes):CDK8 CDK8
CTD Gene:1024 CDK8
dbSNP Gene:1024 CDK8
ENSEMBL:ENSG00000132964 CDK8
ENSEMBL_homo_sapiens_GENE:ENSG00000132964.13 CDK8
HGNC:1779 CDK8
KEGG Gene (Homo sapiens):1024 CDK8
Monarch:1024 CDK8
NCBI Gene:1024 CDK8
OMIM:603184 CDK8
UCSC:P49336 CDK8
Reference Transcript
RefSeq:NM_001318368.1 CDK8
RefSeq:NM_001260.2 CDK8
Other Identifiers
1024
11745882_s_at
11763387_s_at
1189_at
1553112_PM_s_at
1553112_s_at
1553113_PM_s_at
1553113_s_at
16773430
204831_PM_at
204831_at
3482502
3482503
3482504
3482505
3482506
3482507
3482508
3482509
3482522
3482523
3482524
3482536
3482537
3482539
3482540
3482543
3482544
3482546
3482548
3482550
3482553
3482554
35140_at
7968199
A_23_P139958
GE60102
GO:0000151
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006629
GO:0008353
GO:0016301
GO:0016310
GO:0016567
GO:0016592
GO:0016740
GO:0032991
GO:0036211
GO:0043226
GO:0051726
GO:0061630
GO:0090209
GO:0106310
GO:0140096
GO:1990508
HMNXSV003011355
HMNXSV003014489
Hs.25283.0.S2_3p_at
Hs2.397734.1.S1_3p_s_at
Hs2.397734.1.S2_3p_s_at
ILMN_1777913
PH_hs_0019005
TC13000068.hg
TC13000974.hg
X85753_at
p26666
Participates
as a component of
TRAP coactivator complex [nucleoplasm] (Homo sapiens)
DRIP coactivator complex [nucleoplasm] (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
CDK8:CCNC [nucleoplasm] (Homo sapiens)
as an input of
Formation of TRAP coactivator complex (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
Inferred To
Cell division protein kinase 8 [nucleoplasm]
(Mus musculus)
CDK8 [nucleoplasm]
(Bos taurus)
CDK8 [nucleoplasm]
(Caenorhabditis elegans)
CDK8 [nucleoplasm]
(Canis familiaris)
CDK8 [nucleoplasm]
(Danio rerio)
CDK8 [nucleoplasm]
(Dictyostelium discoideum)
CDK8 [nucleoplasm]
(Drosophila melanogaster)
CDK8 [nucleoplasm]
(Gallus gallus)
CDK8 [nucleoplasm]
(Rattus norvegicus)
CDK8 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK8 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK8 [nucleoplasm]
(Sus scrofa)
CDK8 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001251.1
,
NP_001305297.1
ZINC - World Drugs
CDK8_HUMAN
Guide to Pharmacology - Targets
1980
OpenTargets
ENSG00000132964
ZINC - FDA approved
CDK8_HUMAN
ZINC - Substances
CDK8_HUMAN
ZINC - Biogenic
CDK8_HUMAN
ZINC target
P49336
PRO
P49336
PDB
5XS2
,
5HVY
,
5ICP
,
4F7S
,
3RGF
,
4F6W
,
6R3S
,
4CRL
,
6Y0A
,
4F70
,
5I5Z
,
6T41
,
6TPA
,
4F7L
,
5XQX
,
4F7J
,
6QTG
,
5CEI
,
4G6L
,
5HBE
,
4F7N
,
5HBJ
,
4F6U
,
5HNB
,
5IDP
,
5FGK
,
5BNJ
,
4F6S
,
6QTJ
,
5HBH
,
5IDN
ZINC - Investigational
CDK8_HUMAN
HPA
ENSG00000132964-CDK8
GeneCards
P49336
Ensembl
ENST00000381527
,
ENSG00000132964
,
ENSP00000370938
Pharos - Targets
P49336
ZINC - Predictions - Purchasable
CDK8_HUMAN
HMDB Protein
HMDBP01191
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.977
37
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.899
17
UniProt:Q9UHV7 MED13
1
MED13 [nucleoplasm]
(R-HSA-212391)
0.886
18
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.884
14
UniProt:Q96RN5 MED15
1
MED15 [nucleoplasm]
(R-HSA-556827)
0.848
13
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.848
9
UniProt:Q9NWA0 MED9
1
MED9 [nucleoplasm]
(R-HSA-556804)
0.848
9
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.839
9
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.802
8
UniProt:O75448 MED24
1
MED24 [nucleoplasm]
(R-HSA-212331)
0.802
8
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.802
8
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.802
8
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.802
8
UniProt:Q9Y2X0 MED16
1
MED16 [nucleoplasm]
(R-HSA-556802)
0.745
7
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.745
7
UniProt:Q96G25 MED8
1
MED8 [nucleoplasm]
(R-HSA-556784)
0.745
7
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.745
7
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.745
7
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.745
7
UniProt:Q71F56 MED13L
1
MED13L [nucleoplasm]
(R-HSA-556797)
0.745
7
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.745
7
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.745
7
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.745
8
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.725
7
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.671
6
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.671
6
UniProt:Q9H204 MED28
1
MED28 [nucleoplasm]
(R-HSA-6804546)
0.671
6
UniProt:Q9P086 MED11
1
MED11 [nucleoplasm]
(R-HSA-556808)
0.671
6
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.671
6
UniProt:Q92830 KAT2A
1
KAT2A [nucleoplasm]
(R-HSA-3006516)
0.649
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.569
5
UniProt:Q15528 MED22
1
MED22 [nucleoplasm]
(R-HSA-556779)
0.569
5
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.558
4
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.527
4
UniProt:P52739 ZNF131
2
monoSUMO1-K601-ZNF131 [nucleoplasm]
(R-HSA-3296152)
ZNF131 [nucleoplasm]
(R-HSA-3296168)
0.483
3
UniProt:Q96DY7 MTBP
0.483
3
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