Reactome | MED1 [nucleoplasm]

MED1 [nucleoplasm]

Stable Identifier

R-HSA-212445

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
        
        MED1 [nucleoplasm] (Homo sapiens)

General

MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.

External Reference Information

External Reference

UniProt:Q15648 MED1

Gene Names

MED1, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2

Chain

chain:1-1581

Reference Genes

BioGPS Gene:5469 MED1

COSMIC (genes):MED1 MED1

CTD Gene:5469 MED1

dbSNP Gene:5469 MED1

ENSEMBL:ENSG00000125686.12 MED1

HGNC:9234 MED1

KEGG Gene (Homo sapiens):5469 MED1

Monarch:5469 MED1

NCBI Gene:5469 MED1

OMIM:604311 MED1

UCSC:Q15648 MED1

Reference Transcript

RefSeq:NM_004774.3 MED1

Other Identifiers

0001770128

11721007_a_at

11721008_a_at

11721009_at

16844155

203496_PM_s_at

203496_s_at

203497_PM_at

203497_at

225452_PM_at

225452_at

225456_PM_at

225456_at

32064_at

3755697

3755698

3755699

3755700

3755701

3755702

3755716

3755717

3755718

3755719

3755720

3755721

3755722

3755723

3755724

3755725

3755727

3755728

3755729

3755730

3755731

3755732

3755733

3755735

3755736

3755738

3755740

3755741

3755742

3755743

3755744

3755745

3755748

3755749

3755750

44549_at

5469

56136_at

8014841

A_23_P15314

A_23_P425704

A_24_P940666

A_33_P3210423

GE86426

GO:0000122

GO:0000902

GO:0001223

GO:0001525

GO:0001701

GO:0001889

GO:0001892

GO:0002088

GO:0002154

GO:0002376

GO:0003222

GO:0003406

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003714

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0006351

GO:0006354

GO:0006355

GO:0006357

GO:0006575

GO:0006590

GO:0006606

GO:0006629

GO:0006702

GO:0006886

GO:0006913

GO:0007420

GO:0007507

GO:0007595

GO:0008284

GO:0009887

GO:0010628

GO:0010839

GO:0012501

GO:0016020

GO:0016071

GO:0016592

GO:0016922

GO:0022414

GO:0023052

GO:0030154

GO:0030216

GO:0030224

GO:0030331

GO:0030374

GO:0030518

GO:0031100

GO:0032968

GO:0032991

GO:0033148

GO:0033598

GO:0035050

GO:0035116

GO:0035162

GO:0035357

GO:0035729

GO:0035855

GO:0042789

GO:0042809

GO:0042974

GO:0042975

GO:0043010

GO:0043066

GO:0043226

GO:0044877

GO:0045023

GO:0045444

GO:0045618

GO:0045648

GO:0045665

GO:0045893

GO:0045944

GO:0046966

GO:0048821

GO:0048822

GO:0048856

GO:0050693

GO:0051123

GO:0060218

GO:0060261

GO:0060335

GO:0060744

GO:0060745

GO:0060750

GO:0061629

GO:0065003

GO:0070318

GO:0070562

GO:0070847

GO:0071364

GO:0071383

GO:0097067

GO:0098542

GO:0140297

GO:1990841

GO:2000347

GO:2001141

HMNXSV003029846

HMNXSV003047175

Hs.10130.0.A1_3p_at

Hs.10130.0.A2_3p_at

ILMN_1721729

ILMN_3248122

L40366_at

PH_hs_0001448

TC17001449.hg

TC17002613.hg

g3319289_3p_a_at

g4759265_3p_at

Participates

as a component of

as an input of

as a member of

Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)

Inferred To

MED1 [nucleoplasm] (Bos taurus)

MED1 [nucleoplasm] (Canis familiaris)

MED1 [nucleoplasm] (Danio rerio)

MED1 [nucleoplasm] (Dictyostelium discoideum)

MED1 [nucleoplasm] (Drosophila melanogaster)

MED1 [nucleoplasm] (Gallus gallus)

MED1 [nucleoplasm] (Sus scrofa)

MED1 [nucleoplasm] (Xenopus tropicalis)

Med1 [nucleoplasm] (Mus musculus)

Med1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_004765.2

OpenTargets

ENSG00000125686

HPA

ENSG00000125686-MED1

GeneCards

Q15648

Ensembl

ENSP00000300651, ENSG00000125686, ENST00000300651, ENST00000394287, ENSP00000377828

PRO

Q15648

Pharos - Targets

Q15648

Orphanet

29650

PDB

3VJT, 6JEZ, 3WT6, 5XPN, 5AWJ, 5GIE, 5ZWE, 1RKG, 3WT7, 5ZWF, 5XPO, 1RKH, 7VQP, 5XZF, 5XZH, 6D94, 3AUN, 1RJK, 3VJS, 1RK3, 3WTQ, 5B41, 5XUQ, 2O4R, 5ZWH, 3W5R, 2ZFX, 7C7W, 3VRT, 3W5Q, 3W0H, 3VRU, 3W0I, 5AWK, 3W5T, 4YNK, 3VRV, 3W0J, 3A2H, 7ENA, 3VRW, 6K5O, 5XPP, 7ENC, 5ZWI, 7EMF, 5GIC, 7ENJ, 6ONJ, 3W0G, 2O4J, 5GID, 5B5B, 7C7V, 3W5P, 3WT5, 5XPM

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.884	14
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.825	6
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.818	6
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.743	4
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.725	11
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.725	4
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.725	6
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.708	6
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.697	6
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.671	5
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.669	3
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.669	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.643	3
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	3
UniProt:P10827 THRA	1	THRA [nucleoplasm] (R-HSA-446180)	0.591	4
UniProt:P15976 GATA1	1	GATA1 [nucleoplasm] (R-HSA-996772)	0.582	6
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.564	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.527	2
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.527	2
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.527	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.527	2
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	3
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.527	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q96R06 SPAG5			0.508	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.483	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.471	2
UniProt:Q92731 ESR2	5	Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.462	2

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