Reactome | PRKCD(330-676) [cytosol]

PRKCD(330-676) [cytosol]

Stable Identifier

R-HSA-212551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKC-delta fragment (330-676)

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q05655 PRKCD

Gene Names

PRKCD, PKCD

Chain

chain:1-676, chain:1-329, chain:330-676

Reference Genes

BioGPS Gene:5580 PRKCD

COSMIC (genes):PRKCD PRKCD

CTD Gene:5580 PRKCD

dbSNP Gene:5580 PRKCD

ENSEMBL:ENSG00000163932 PRKCD

HGNC:9399 PRKCD

KEGG:hsa:5580 PRKCD

Monarch:5580 PRKCD

NCBI Gene:5580 PRKCD

OMIM:176977 PRKCD

UCSC:Q05655 PRKCD

Reference Transcript

Other Identifiers

11727841_a_at

11736573_a_at

16941781

1810_s_at

202545_PM_at

202545_at

2624288

2624292

2624293

2624294

2624303

2624304

2624305

2624306

2624307

2624308

2624309

2624310

2624311

2624313

2624314

2624315

2624316

2624317

2624318

2624319

2624320

2624321

2624322

2624323

2624324

2624325

2624326

2624327

2624329

2624330

2624331

2624333

2624334

2624335

32046_at

5580

8080487

A_14_P104518

A_14_P138877

A_23_P144054

A_33_P3350580

D10495_at

GE57042

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004699

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005773

GO:0005783

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006915

GO:0006974

GO:0007165

GO:0008047

GO:0008631

GO:0012501

GO:0012505

GO:0016020

GO:0016064

GO:0016363

GO:0016740

GO:0018105

GO:0018107

GO:0019899

GO:0019901

GO:0023021

GO:0030837

GO:0031410

GO:0032079

GO:0032147

GO:0032930

GO:0032956

GO:0034351

GO:0034644

GO:0035307

GO:0035556

GO:0035578

GO:0036019

GO:0038096

GO:0042100

GO:0042119

GO:0042307

GO:0042742

GO:0043005

GO:0043226

GO:0043407

GO:0043488

GO:0043560

GO:0043687

GO:0045202

GO:0046627

GO:0046872

GO:0048471

GO:0048870

GO:0050728

GO:0050732

GO:0050821

GO:0051490

GO:0060326

GO:0061024

GO:0070062

GO:0070301

GO:0071398

GO:0071447

GO:0080090

GO:0090331

GO:0090398

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:1900163

GO:1904385

GO:2000303

GO:2000304

GO:2000753

GO:2000755

GO:2001235

HMNXSV003010905

HMNXSV003051624

ILMN_1682813

ILMN_1801105

PH_hs_0009356

TC03000348.hg

TC03002349.hg

g5453969_3p_at

Participates

as an output of

Caspase 3-mediated cleavage of PKC delta (Homo sapiens)

Other forms of this molecule

PRKCD [cytosol]

PRKCD(1-329) [cytosol]

p-T507,S645,S664-PRKCD(1-676) [plasma membrane]

active p-T507,S645,S664-PRKCD [plasma membrane]

p-T507,S645,S664-PRKCD [cytosol]

p-T507-PRKCD [cytosol]

PRKCD(330-676) [azurophil granule lumen]

PRKCD(1-329) [azurophil granule lumen]

PRKCD(1-329) [extracellular region]

PRKCD(330-676) [extracellular region]

PRKCD(1-676) [nucleoplasm]

Inferred To

Homologues of PRKCD(330-676) [cytosol] (Dictyostelium discoideum)

Homologues of PRKCD(330-676) [cytosol] (Schizosaccharomyces pombe)

PRKCD(330-676) [cytosol] (Bos taurus)

PRKCD(330-676) [cytosol] (Caenorhabditis elegans)

PRKCD(330-676) [cytosol] (Danio rerio)

PRKCD(330-676) [cytosol] (Dictyostelium discoideum)

PRKCD(330-676) [cytosol] (Drosophila melanogaster)

PRKCD(330-676) [cytosol] (Mus musculus)

PRKCD(330-676) [cytosol] (Rattus norvegicus)

PRKCD(330-676) [cytosol] (Saccharomyces cerevisiae)

PRKCD(330-676) [cytosol] (Schizosaccharomyces pombe)

PRKCD(330-676) [cytosol] (Sus scrofa)

PRKCD(330-676) [cytosol] (Xenopus tropicalis)

PRKCD [cytosol] (Canis familiaris)

PRKCD [cytosol] (Gallus gallus)

Cross References

RefSeq

XP_016862345.1, XP_016862344.1, XP_006713322.1, NP_001303256.1, NP_006245.2, NP_997704.1

ZINC - World Drugs

KPCD_HUMAN

Guide to Pharmacology - Targets

1485

ENSEMBL

ENSP00000331602, ENST00000652449, ENST00000330452, ENST00000650739, ENSP00000498400, ENSP00000498623, ENST00000654719, ENSP00000378217, ENST00000394729, ENSP00000499558

OpenTargets

ENSG00000163932

ZINC - FDA approved

KPCD_HUMAN

ZINC - Substances

KPCD_HUMAN

ZINC - Biogenic

KPCD_HUMAN

ZINC target

Q05655

PRO

Q05655

PDB

2YUU, 1YRK

ZINC - Investigational

KPCD_HUMAN

ZINC - Metabolites

KPCD_HUMAN

IntEnz

2.7.11.13, 2.7.10.2

HPA

ENSG00000163932-PRKCD

Pharos - Targets

Q05655

Orphanet

PRKCD

ZINC - Predictions - Purchasable

KPCD_HUMAN

HMDB Protein

HMDBP01847

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.737	5
UniProt:P24001-2 IL32			0.728	7
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.679	10
UniProt:Q9H5V8 CDCP1			0.675	7
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.619	7
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.602	4
UniProt:P17677 GAP43	2	GAP43 [plasma membrane] (R-HSA-452888) PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482)	0.602	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:P19878 NCF2	2	NCF2 [cytosol] (R-HSA-1222600) p-T233-NCF2 [phagolysosome] (R-HSA-1996211)	0.544	3
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.527	2
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.527	2
UniProt:P05771 PRKCB	5	PRKCB [cytosol] (R-HSA-58198) p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500-PRKCB [cytosol] (R-HSA-5218728) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294) PRKCB [plasma membrane] (R-HSA-156467)	0.527	2
UniProt:P57078 RIPK4			0.527	2
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.527	3
UniProt:Q12816 TROP			0.463	2
UniProt:C6GKH1 C6GKH1			0.463	3

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